H Rex Gaskins
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Explore the profile of H Rex Gaskins including associated specialties, affiliations and a list of published articles.
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99
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5123
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Recent Articles
1.
Wolf P, Welsh C, Binion B, Dai H, Oliveira M, Hamm A, et al.
J Nutr
. 2025 Jan;
155(3):826-838.
PMID: 39805403
Background: Accumulation of hydrophobic bile acids (BAs) is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory...
2.
Iyer R, Applegate C, Arogundade O, Bangru S, Berg I, Emon B, et al.
Heliyon
. 2024 Jul;
10(12):e32546.
PMID: 38975228
Understanding the molecular and physical complexity of the tissue microenvironment (TiME) in the context of its spatiotemporal organization has remained an enduring challenge. Recent advances in engineering and data science...
3.
Ridlon J, Gaskins H
Nat Rev Gastroenterol Hepatol
. 2024 Feb;
21(5):348-364.
PMID: 38383804
The field of bile acid microbiology in the gastrointestinal tract is going through a current rebirth after a peak of activity in the late 1970s and early 1980s. This renewed...
4.
Lumibao J, Haak P, Kolossov V, Chen J, Stutchman J, Ruiz A, et al.
Int J Oncol
. 2023 Sep;
63(5).
PMID: 37654190
Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration,...
5.
The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology
Ridlon J, Daniel S, Gaskins H
J Lipid Res
. 2023 May;
64(8):100392.
PMID: 37211250
Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids, remove cholesterol from the body, and act as nutrient signaling molecules in numerous tissues with functions in...
6.
Yazici C, Thaker S, Castellanos K, Al Rashdan H, Huang Y, Sarraf P, et al.
Clin Transl Gastroenterol
. 2023 May;
14(7):e00597.
PMID: 37162146
Introduction: Diet and decreased gut microbiome diversity has been associated with acute pancreatitis (AP) risk. However, differences in dietary intake, gut microbiome, and their impact on microbial end metabolites have...
7.
McLeod A, Wolf P, Chapkin R, Davidson L, Ivanov I, Berbaum M, et al.
Trials
. 2023 Feb;
24(1):113.
PMID: 36793105
Background: Among all racial/ethnic groups, people who identify as African American/Blacks have the second highest colorectal cancer (CRC) incidence in the USA. This disparity may exist because African American/Blacks, compared...
8.
Wolf P, Penalver Bernabe B, Oliveira M, Hamm A, McLeod A, Olender S, et al.
Nutr Cancer
. 2023 Jan;
75(3):876-889.
PMID: 36625531
Obesity is considered an independent risk factor for colorectal cancer (CRC). Altered nutrient metabolism, particularly changes to digestion and intestinal absorption, may play an important role in the development of...
9.
Lee J, Cowley E, Wolf P, Doden H, Murai T, Olivos Caicedo K, et al.
Gut Microbes
. 2022 Nov;
14(1):2132903.
PMID: 36343662
The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids, which are responsible for intestinal lipid digestion and function as key nutrient-signaling molecules. The human liver produces...
10.
Wolf P, Cowley E, Breister A, Matatov S, Lucio L, Polak P, et al.
Microbiome
. 2022 Apr;
10(1):64.
PMID: 35440042
Background: Recent evidence implicates microbial sulfidogenesis as a potential trigger of colorectal cancer (CRC), highlighting the need for comprehensive knowledge of sulfur metabolism within the human gut. Microbial sulfidogenesis produces...