H R Sagara Wijeratne
Overview
Explore the profile of H R Sagara Wijeratne including associated specialties, affiliations and a list of published articles.
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17
Citations
282
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Recent Articles
1.
Tate M, Wijeratne H, Kim B, Philtjens S, You Y, Lee D, et al.
Alzheimers Dement
. 2024 Sep;
20(11):7805-7818.
PMID: 39345217
Introduction: Rare variants in ABCA1 increase the risk of developing Alzheimer's disease (AD). ABCA1 facilitates the lipidation of apolipoprotein E (apoE). This study investigated whether microRNA-33 (miR-33)-mediated regulation of this...
2.
Runnebohm A, Wijeratne H, Justice S, Wijeratne A, Roy G, Singh N, et al.
bioRxiv
. 2024 May;
PMID: 38798459
Background: Triple negative breast cancer (TNBC), characterized by the lack of three canonical receptors, is unresponsive to commonly used hormonal therapies. One potential TNBC-specific therapeutic target is NQO1, as it...
3.
Kim B, Dabin L, Tate M, Karahan H, Sharify A, Acri D, et al.
Nat Commun
. 2024 May;
15(1):3996.
PMID: 38734693
SPI1 was recently reported as a genetic risk factor for Alzheimer's disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to...
4.
Acri D, You Y, Tate M, Karahan H, Martinez P, McCord B, et al.
J Exp Med
. 2023 Aug;
220(11).
PMID: 37606887
Previous research demonstrated that genetic heterogeneity is a critical factor in modeling amyloid accumulation and other Alzheimer's disease phenotypes. However, it is unknown what mechanisms underlie these effects of genetic...
5.
McCracken N, Liu H, Runnebohm A, Wijeratne H, Wijeratne A, Staschke K, et al.
Mol Cell Proteomics
. 2023 Aug;
22(9):100630.
PMID: 37562535
Thermal proteome profiling (TPP) is an invaluable tool for functional proteomics studies that has been shown to discover changes associated with protein-ligand, protein-protein, and protein-RNA interaction dynamics along with changes...
6.
Acri D, You Y, Tate M, McCord B, Sharify A, John S, et al.
bioRxiv
. 2023 Feb;
PMID: 36778440
Summary: Seeding of tau predates the phosphorylation and spreading of tau aggregates. Acri and colleagues report transcriptomic responses to tau and elevated tau seeds in wild-derived mice. This paper creates...
7.
Smith D, Karahan H, Wijeratne H, Al-Amin M, McCord B, Moon Y, et al.
Front Aging Neurosci
. 2023 Jan;
14:1035572.
PMID: 36620768
Alzheimer's disease (AD) genetics studies have identified a coding variant within gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the gene locus dramatically exacerbates...
8.
Karahan H, Smith D, Kim B, Dabin L, Al-Amin M, Wijeratne H, et al.
Sci Adv
. 2021 Nov;
7(45):eabe3954.
PMID: 34731000
Recently, large-scale human genetics studies identified a rare coding variant in the gene that is associated with an increased risk of Alzheimer’s disease (AD). However, pathways by which ABI3 contributes...
9.
Campos R, Wijeratne H, Shah P, Garcia-Blanco M, Bradrick S
Nucleic Acids Res
. 2020 Sep;
48(17):9872-9885.
PMID: 32890404
The ribosomal stalk proteins, RPLP1 and RPLP2 (RPLP1/2), which form the ancient ribosomal stalk, were discovered decades ago but their functions remain mysterious. We had previously shown that RPLP1/2 are...
10.
Justice S, Barron M, Qi G, Wijeratne H, Victorino J, Simpson E, et al.
J Biol Chem
. 2020 Sep;
295(48):16219-16238.
PMID: 32878984
Temperature-sensitive (TS) missense mutants have been foundational for characterization of essential gene function. However, an unbiased approach for analysis of biochemical and biophysical changes in TS missense mutants within the...