H Major
Overview
Explore the profile of H Major including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
170
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Recent Articles
1.
Williams R, Lenz E, Wilson A, Granger J, Wilson I, Major H, et al.
Mol Biosyst
. 2006 Aug;
2(3-4):174-83.
PMID: 16880935
Plasma obtained from 20 week old normal Wistar-derived and Zucker (fa/fa) rats was analysed using a number of different analytical methodologies to obtain global metabolite profiles as part of metabonomic...
2.
Lenz E, Bright J, Knight R, Westwood F, Davies D, Major H, et al.
Biomarkers
. 2005 Aug;
10(2-3):173-87.
PMID: 16076731
The model nephrotoxin gentamicin was administered to male Wistar-derived rats daily, for 7 days, at 60 mg kg-1 day-1, subcutaneously, twice daily. Conventional clinical chemistry urinalysis showed a significant increase...
3.
Williams R, Major H, Lock E, Lenz E, Wilson I
Toxicology
. 2004 Dec;
207(2):179-90.
PMID: 15596249
HPLC-MS-based metabonomic analysis was used to investigate urinary metabolic perturbations associated with D-serine-induced nephrotoxicity. D-Serine causes selective necrosis of the proximal straight tubules in the rat kidney accompanied by aminoaciduria,...
4.
Lenz E, Bright J, Knight R, Wilson I, Major H
Analyst
. 2004 May;
129(6):535-41.
PMID: 15152332
The effects of the administration of a single dose of the model nephrotoxin mercuric chloride (2.0 mg kg(-1), subcutaneous) to male Wistar-derived rats on the urinary metabolite profiles of a...
5.
Lenz E, Bright J, Knight R, Wilson I, Major H
J Pharm Biomed Anal
. 2004 May;
35(3):599-608.
PMID: 15137985
The model nephrotoxin cyclosporin A was administered to male Wistar-derived rats daily for 9 days at a dose level of 45 mg/kg per day. Urine samples were collected daily and...
6.
Major H, Castro-Perez J, Nicholson J, Wilson I
Xenobiotica
. 2003 Aug;
33(8):855-69.
PMID: 12936705
1. The metabolic fate of 4-bromoaniline (4-BrA) was investigated in rat following intraperitoneal administration at 50 mg kg(-1) using HPLC-TOF-MS/MS. 2. The sensitivity provided by the use of TOF-MS/MS, aided...
7.
Bobeldijk I, Vissers J, Kearney G, Major H, van Leerdam J
J Chromatogr A
. 2001 Oct;
929(1-2):63-74.
PMID: 11594404
In order to assess and maintain the quality of surface waters, target compound monitoring is often not sufficient. Many unknown micro-contaminants are present in water, originating in municipal, industrial or...
8.
Major H, Ward K
J Reprod Immunol
. 1998 Jun;
38(1):55-61.
PMID: 9616877
Preeclampsia is associated with increased plasma concentrations of tumor necrosis factor alpha (TNF alpha) and TNF receptors. A mutation in the promoter region of the TNF alpha gene (TNF T2)...
9.
Major H, Varner M, Ward K
Am J Obstet Gynecol
. 1997 Nov;
177(4):810-3.
PMID: 9369824
Objective: Increased amniotic fluid concentrations of tumor necrosis factor-alpha are observed in women with preterm labor and subsequent preterm birth. We tested whether a mutation in the promoter region of...
10.
El-Shanti H, Khasawneh M, Hulsberg D, Major H, Patil S
Ann Genet
. 1997 Jan;
40(3):175-80.
PMID: 9401108
Individuals with free and total trisomy 12 are rare and always mosaic. Incidences of partial trisomy 12 are more frequent and are classified into trisomy 12p and trisomy 12q. The...