H M Duhart
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Explore the profile of H M Duhart including associated specialties, affiliations and a list of published articles.
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12
Citations
159
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Recent Articles
1.
Wang C, Sadovova N, Ali H, Duhart H, Fu X, Zou X, et al.
Neuroscience
. 2006 Nov;
144(1):46-55.
PMID: 17084538
1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with an elevation of intracellular reactive...
2.
Xu Z, Cawthon D, McCastlain K, Duhart H, Newport G, Fang H, et al.
Neurotoxicology
. 2005 Aug;
26(4):729-37.
PMID: 16112330
MPP(+) (1-methyl-4-phenylpyridinium; the active metabolite of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine)) depletes dopamine (DA) content and elicits cell death in PC12 cells. However, the mechanism of MPP(+)-induced neurotoxicity is still unclear....
3.
Santamaria A, Galvan-Arzate S, Lisy V, Ali S, Duhart H, Osorio-Rico L, et al.
Neuroreport
. 2001 Mar;
12(4):871-4.
PMID: 11277599
The oxidative action of quinolinic acid (QUIN), and the protective effects of glutathione (GSH), and 2-amino-5-phosphonovaleric acid (APV), were tested in rat brain synaptosomes, Reactive oxygen species (ROS) formation was...
4.
Bailey B, Morris P, McMartin K, Klein J, Duhart H, Gillam M, et al.
Reprod Toxicol
. 1998 Oct;
12(5):517-23.
PMID: 9763243
There is large variability in the rate and extent of fetal damage from cocaine in humans; however, the sources of such variability are not presently known. In order to study...
5.
Hussain S, Rodgers D, Duhart H, Ali S
J Environ Sci Health B
. 1997 May;
32(3):395-409.
PMID: 9177012
The present study was undertaken to determine if in vitro exposure to mercuric chloride produces reactive oxygen species (ROS) in the synaptosomes prepared from various regions of rat brain. The...
6.
Morris P, Binienda Z, Gillam M, Klein J, McMartin K, Koren G, et al.
Neurotoxicol Teratol
. 1997 Jan;
19(1):47-57.
PMID: 9088010
To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5...
7.
Sandberg J, Duhart H, Lipe G, Binienda Z, Slikker Jr W, Kim C
J Toxicol Environ Health
. 1996 Dec;
49(5):497-509.
PMID: 8968410
The distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) was examined in maternal and fetal rabbits. Pregnant New Zealand rabbits (28-30 d gestational age) were anesthetized with ketamine/xylazine and the femoral vein and...
8.
Ali S, Duhart H, Newport G, Lipe G, Slikker Jr W
Neurodegeneration
. 1995 Sep;
4(3):329-34.
PMID: 8581566
Manganese (Mn) is an essential element, the deficiency or excess of which is known to cause neurotoxicity in experimental animals and man. The mechanism of action of Mn neurotoxicity is...
9.
Duhart H, Fogle C, Gillam M, Bailey J, Slikker Jr W, Paule M
Reprod Toxicol
. 1993 Sep;
7(5):429-37.
PMID: 8274818
To determine pharmacokinetic parameters for cocaine in rhesus monkey plasma, samples were taken over several hours after i.m. administration of cocaine plus a tritiated cocaine tracer. Cocaine and its metabolites,...
10.
Binienda Z, Bailey J, Duhart H, Slikker Jr W, Paule M
Drug Metab Dispos
. 1993 Mar;
21(2):364-8.
PMID: 8097710
The transplacental pharmacokinetics of cocaine were studied in three pregnant rhesus monkeys (Macaca mulatta) at 150-154 days of pregnancy (term approximately 165 days). Animals were dosed intramuscularly with cocaine hydrochloride...