H KROTH
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Explore the profile of H KROTH including associated specialties, affiliations and a list of published articles.
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16
Citations
122
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Recent Articles
1.
Peletskaya E, Boyer P, Kogon A, Clark P, KROTH H, Sayer J, et al.
J Virol
. 2001 Sep;
75(19):9435-45.
PMID: 11533206
Cross-linking experiments were performed with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (positions 65, 67, 70, and 74) in the...
2.
Ponten I, KROTH H, Sayer J, Dipple A, Jerina D
Chem Res Toxicol
. 2001 Jun;
14(6):720-6.
PMID: 11409943
The four adducts at N(2) of deoxyguanosine derived from cis-opening at C-10 of four optically active isomers of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene were incorporated into 5'-TTCGAATCCTTCCCCC [context III(G)] and 5'-GGGGTTCCCGAGCGGC [context IV(G)] at...
3.
KROTH H, Yagi H, Sayer J, Kumar S, Jerina D
Chem Res Toxicol
. 2001 Jun;
14(6):708-19.
PMID: 11409942
We describe a synthetic strategy for the preparation of oligonucleotides using N(2)-alkylated and O(6)-allyl protected deoxyguanosine phosphoramidite building blocks derived from cis- and trans-opened (+/-)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene and (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene and from trans-opened...
4.
Ramesha A, KROTH H, Jerina D
Org Lett
. 2001 Feb;
3(4):531-3.
PMID: 11178817
[reaction: see text] The first solid-state (or solvent-free) synthesis of protected deoxyguanosine (dG) adducts of benzo[a]pyrene diol epoxides at room temperature is reported. Whereas dG adducts derived from cis- and...
5.
Pommier Y, Laco G, Kohlhagen G, Sayer J, KROTH H, Jerina D
Proc Natl Acad Sci U S A
. 2000 Sep;
97(20):10739-44.
PMID: 10995470
DNA topoisomerase I (top1) is the target of potent anticancer agents, including camptothecins and DNA intercalators, which reversibly stabilize (trap) top1 catalytic intermediates (cleavage complexes). The aim of the present...
6.
KROTH H, Yagi H, Seidel A, Jerina D
J Org Chem
. 2000 Sep;
65(18):5558-64.
PMID: 10970294
We describe a new and facile method for the synthesis of both cis- and trans-opened N(2)-deoxyguanosine (dG) adducts of (+/-)-7alpha, 8beta-dihydoxy-9beta,10beta-epoxy-7,8,9,10-tetra hydrobenzo[a]pyrene and (+/-)-7alpha,8beta-dihydoxy-9alpha,10alpha -epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene at C-10. The key...
7.
Buterin T, Hess M, Luneva N, Geacintov N, Amin S, KROTH H, et al.
Cancer Res
. 2000 Apr;
60(7):1849-56.
PMID: 10766171
The fjord region diol-epoxide metabolites of polycyclic aromatic hydrocarbons display stronger tumorigenic activities in rodent studies than comparable bay region diol-epoxides, but the molecular basis for this difference between fjord...
8.
Pommier Y, Kohlhagen G, Pourquier P, Sayer J, KROTH H, Jerina D
Proc Natl Acad Sci U S A
. 2000 Feb;
97(5):2040-5.
PMID: 10688881
The catalytic intermediates of DNA topoisomerase I (top1) are cleavage complexes that can relax DNA supercoiling (intramolecular reaction) or mediate recombinations (intermolecular religation). We report here that DNA adducts formed...
9.
Li K, George M, Gross M, Lin C, Jankowiak R, Small G, et al.
Chem Res Toxicol
. 1999 Sep;
12(9):778-88.
PMID: 10490498
(+/-)-anti-Dibenzo[a,l]pyrene-11,12-dihydrodiol 13,14-epoxide {(+/-)-anti-DB[a,l]PDE} was reacted with deoxyguanosine (dG) in dimethylformamide at 100 degrees C for 30 min, and two sets of adducts were isolated: a mixture of (+/-)-anti-cis- & -trans-N(2)dG...
10.
Jankowiak R, Ariese F, Zamzow D, Luch A, KROTH H, Seidel A, et al.
Chem Res Toxicol
. 1997 Jun;
10(6):677-86.
PMID: 9208175
An understanding of the conformational behavior of the stereoisomeric tetrols at the 11,12,13,14-positions of dibenzo[a,l]pyrene (DB[a,l]P) is essential for the spectroscopic identification of DNA adducts derived from the biologically highly...