H K Jajoo
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Explore the profile of H K Jajoo including associated specialties, affiliations and a list of published articles.
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16
Citations
39
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Recent Articles
1.
Reddy K, Lohray B, Bhushan V, Bajji A, Reddy K, Reddy P, et al.
J Med Chem
. 1999 Jun;
42(11):1927-40.
PMID: 10354401
Several thiazolidinedione derivatives having 5-hydroxy-2,3-dihydro-2, 2,4,6,7-pentamethylbenzofuran moieties and their 5-benzyloxy derivatives and 5-hydroxy-2,4,6,7-tetramethylbenzofuran moieties were synthesized and evaluated in db/db mice. Insertion of an N-Me group into the linker between...
2.
Jajoo H, Mamidi R, Vakkalanka S, Sathyavageeswaran S, Katneni K, Ayalasomayajula P, et al.
Arzneimittelforschung
. 1999 Mar;
49(2):133-6.
PMID: 10083982
The pharmacokinetics of the new insulin sensitizing agent, DRF-2189 ([5-[4-[2-(1-indolyl) ethoxy]phenyl]methyl]thiazolidine-2,4-dione, CAS 172647-53-9) were studied in male Wistar rats following oral doses of 1, 3 and 10 mg/kg as suspension...
3.
Jajoo H, Rao Mamidi N, Kasiram K, Prakash A, Swaroop Kumar V, Rao P, et al.
J Chromatogr B Biomed Sci Appl
. 1998 Jun;
707(1-2):241-6.
PMID: 9613956
A high-performance liquid chromatographic method for the determination of DRF-2189, using troglitazone as internal standard, is described. A dichloromethane-ethyl acetate solvent mixture (6:4, v/v) was used as the extraction solvent....
4.
Lohray B, Bhushan V, Rao B, Madhavan G, Murali N, Rao K, et al.
J Med Chem
. 1998 May;
41(10):1619-30.
PMID: 9572887
A series of [[(heterocyclyl)ethoxy]benzyl]-2,4-thiazolidinediones have been synthesized by the condensation of corresponding aldehyde 1 and 2,4-thiazolidinedione followed by hydrogenation. Both unsaturated thiazolidinedione 2 and its saturated counterpart 3 have shown...
5.
Kim S, Jajoo H, Kim H, Zhou L, Horton P, Harris C, et al.
Bioorg Med Chem
. 1995 Jun;
3(6):811-22.
PMID: 7582958
Polycyclic aromatic hydrocarbons are metabolized to a wide variety of oxidized derivatives, including highly reactive diol epoxides which alkylate DNA. The reaction lacks regio- or stereospecificity but occurs primarily at...
6.
Jajoo H, Burcham P, Goda Y, Blair I, Marnett L
Chem Res Toxicol
. 1992 Nov;
5(6):870-5.
PMID: 1489939
A method is described for detection and quantitation of the major malondialdehyde-guanine adduct (M1G) based on thermospray liquid chromatography/mass spectrometry. A stable isotope analog of M1G ([2H2]M1G) was used as...
7.
Jajoo H, Bennett S, Kornhauser D
J Chromatogr
. 1992 Jun;
577(2):299-304.
PMID: 1328268
Thermospray liquid chromatography-mass spectrometry was investigated as a method for quantification of 2',3'-dideoxycytidine (DDC) from human plasma. A stable isotope analog of DDC ([15N2,2H2]DDC) was used as an internal standard....
8.
Jajoo H, Capdevila J, Falck J, Bhatt R, Blair I
Biochim Biophys Acta
. 1992 Jan;
1123(1):110-6.
PMID: 1730042
The in vitro metabolism of 12(R)-hydroxyeicosatetraenoic acid was studied using freshly isolated rat liver microsomes. Ten metabolites were isolated and identified by a combination of ultraviolet spectroscopy and gas chromatography/mass...
9.
Mayol R, Jajoo H, Klunk L, Blair I
Drug Metab Dispos
. 1991 Mar;
19(2):394-9.
PMID: 1676643
Metabolism of the antipsychotic drug tiospirone was studied in humans after a single 60-mg oral dose of [14C]tiospirone. Metabolites were isolated from a 0-24 hr pooled urine from eight subjects,...
10.
Jajoo H, Prakash C, Mayol R, Blair I
Biochem Pharmacol
. 1990 Aug;
40(4):893-5.
PMID: 2117457
No abstract available.