H J W Thomas
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Explore the profile of H J W Thomas including associated specialties, affiliations and a list of published articles.
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14
Citations
752
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Recent Articles
1.
Beggs A, Latchford A, Vasen H, Moslein G, Alonso A, Aretz S, et al.
Gut
. 2010 Jun;
59(7):975-86.
PMID: 20581245
Peutz-Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal tract and mucocutaneous pigmentation. The majority of patients that meet the...
2.
Vasen H, Moslein G, Alonso A, Aretz S, Bernstein I, Bertario L, et al.
Fam Cancer
. 2009 Sep;
9(2):109-15.
PMID: 19763885
Familial colorectal cancer (CRC) accounts for 10-15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited syndrome. The most common inherited...
3.
Schmulewitz L, Attard N, Fearfield L, Westaby D, Prasad P, Thomas H, et al.
Br J Dermatol
. 2008 May;
159(1):228-30.
PMID: 18503591
We present a patient with an unusual enterocutaneous syndrome. Long-term, low-dose acitretin treatment has stabilized the development of gastrointestinal lesions while synchronously reducing cutaneous morbidity.
4.
Vasen H, Moslein G, Alonso A, Aretz S, Bernstein I, Bertario L, et al.
Gut
. 2008 Jan;
57(5):704-13.
PMID: 18194984
Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to...
5.
Jones A, Thirlwell C, Howarth K, Graham T, Chambers W, Segditsas S, et al.
J Pathol
. 2007 Sep;
213(3):249-56.
PMID: 17893889
We have examined chromosomal-scale mutations in 34 large colorectal adenomas (CRAs). A small number of changes (median = 2, IQR = 0-4) were found by array-comparative genomic hybridization (aCGH) in...
6.
East J, Suzuki N, Stavrinidis M, Guenther T, Thomas H, Saunders B
Gut
. 2007 Aug;
57(1):65-70.
PMID: 17682000
Background: Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a...
7.
Thirlwell C, Howarth K, Segditsas S, Guerra G, Thomas H, Phillips R, et al.
Br J Cancer
. 2007 May;
96(11):1729-34.
PMID: 17505512
Patients with multiple (5-100) colorectal adenomas (MCRAs) often have no germline mutation in known predisposition genes, but probably have a genetic origin. We collected a set of 25 MCRA patients...
8.
Carvajal-Carmona L, Howarth K, Lockett M, Polanco-Echeverry G, Volikos E, Gorman M, et al.
J Pathol
. 2007 May;
212(4):378-85.
PMID: 17503413
Hyperplastic Polyposis (HPPS) is a poorly characterized syndrome that increases colorectal cancer (CRC) risk. We aimed to provide a molecular classification of HPPS. We obtained 282 tumours from 32 putative...
9.
Johnson V, Lipton L, Cummings C, Eftekhar Sadat A, Izatt L, Hodgson S, et al.
J Med Genet
. 2005 Mar;
42(10):756-62.
PMID: 15788729
Objective: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). Methods: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss...
10.
Lipton L, Johnson V, Cummings C, Fisher S, Risby P, Eftekhar Sadat A, et al.
J Clin Oncol
. 2004 Dec;
22(24):4934-43.
PMID: 15611508
Purpose: Hereditary nonpolyposis colon cancer (HNPCC) is a Mendelian dominant syndrome of bowel, endometrial, and other cancers and results from germline mutations in mismatch repair (MMR) genes. HNPCC is now...