O M Sieber
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Explore the profile of O M Sieber including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
309
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Recent Articles
1.
Sakthianandeswaren A, Liu S, Sieber O
Cell Death Discov
. 2016 Aug;
2:16059.
PMID: 27551547
No abstract available.
2.
Christie M, Jorissen R, Mouradov D, Sakthianandeswaren A, Li S, Day F, et al.
Oncogene
. 2012 Oct;
32(39):4675-82.
PMID: 23085758
Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/β-catenin signalling levels 'just-right' for...
3.
Segditsas S, Rowan A, Howarth K, Jones A, Leedham S, Wright N, et al.
Oncogene
. 2008 Oct;
28(1):146-55.
PMID: 18836487
The seminal 'two-hit hypothesis' implicitly assumes that bi-allelic tumour suppressor gene (TSG) mutations cause loss of protein function. All subsequent events in that tumour therefore take place on an essentially...
4.
Jones A, Thirlwell C, Howarth K, Graham T, Chambers W, Segditsas S, et al.
J Pathol
. 2007 Sep;
213(3):249-56.
PMID: 17893889
We have examined chromosomal-scale mutations in 34 large colorectal adenomas (CRAs). A small number of changes (median = 2, IQR = 0-4) were found by array-comparative genomic hybridization (aCGH) in...
5.
Thirlwell C, Howarth K, Segditsas S, Guerra G, Thomas H, Phillips R, et al.
Br J Cancer
. 2007 May;
96(11):1729-34.
PMID: 17505512
Patients with multiple (5-100) colorectal adenomas (MCRAs) often have no germline mutation in known predisposition genes, but probably have a genetic origin. We collected a set of 25 MCRA patients...
6.
Sieber O, Segditsas S, Knudsen A, Zhang J, Luz J, Rowan A, et al.
Gut
. 2006 Feb;
55(10):1440-8.
PMID: 16461775
Background: Attenuated familial adenomatous polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene. These mutations probably encode a...
7.
Lipton L, Sieber O, Thomas H, Hodgson S, Tomlinson I, Woodford-Richens K
J Med Genet
. 2003 Apr;
40(4):e35.
PMID: 12676908
No abstract available.
8.
Sieber O, Heinimann K, Gorman P, Lamlum H, Crabtree M, Simpson C, et al.
Proc Natl Acad Sci U S A
. 2002 Dec;
99(26):16910-5.
PMID: 12486240
In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These...
9.
Sieber O, Lamlum H, Crabtree M, Rowan A, Barclay E, Lipton L, et al.
Proc Natl Acad Sci U S A
. 2002 Feb;
99(5):2954-8.
PMID: 11867715
Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene (chromosome 5q21). FAP shows substantial phenotypic variability: classical polyposis patients...
10.
Sieber O, Tomlinson I, Lamlum H
Mol Med Today
. 2000 Dec;
6(12):462-9.
PMID: 11099951
Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of...