H J van der Wiel
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Explore the profile of H J van der Wiel including associated specialties, affiliations and a list of published articles.
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16
Citations
52
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Recent Articles
1.
Spruit H, Langenberg J, Trap H, van der Wiel H, Helmich R, van Helden H, et al.
Toxicol Appl Pharmacol
. 2001 Jan;
169(3):249-54.
PMID: 11133347
We report the first toxicokinetic studies of (+/-)-sarin. The toxicokinetics of the stereoisomers of this nerve agent were studied in anesthetized, atropinized, and restrained guinea pigs after intravenous bolus administration...
2.
Benschop H, Trap H, Spruit H, van der Wiel H, Langenberg J, DE JONG L
Toxicol Appl Pharmacol
. 1999 Jan;
153(2):179-85.
PMID: 9878589
In order to initiate a quantitative basis for the toxicology of low level exposure to nerve agents, the toxicokinetics of soman stereoisomers during nose-only exposure for 5 h to 20...
3.
Langenberg J, Spruit H, van der Wiel H, Trap H, Helmich R, Bergers W, et al.
Toxicol Appl Pharmacol
. 1998 Aug;
151(1):79-87.
PMID: 9705889
The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were studied in anesthetized, atropinized guinea pigs for nose-only exposure to soman vapor. During exposure the respiratory minute volume...
4.
Busker R, Zijlstra J, van der Wiel H, van Helden H
Neurochem Res
. 1994 Jun;
19(6):713-9.
PMID: 8065529
The severity of poisoning following acetylcholinesterase (AChE) inhibition correlates weakly with total AChE activity. This may be partly due to the existence of functional and non-functional pools of AChE. AChE...
5.
van Helden H, van der Wiel H, Zijlstra J, Melchers B, Busker R
Arch Toxicol
. 1994 Jan;
68(4):224-30.
PMID: 8067894
The oximes HI-6, HLö-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic effects of oximes other than acetylcholinesterase (AChE) reactivation (so-called "non-reactivating...
6.
Due A, Trap H, van der Wiel H, Benschop H
Arch Toxicol
. 1993 Jan;
67(10):706-11.
PMID: 8135661
Pretreatment of rats and guinea pigs with the specific carboxylesterase inhibitor 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP) reduces the LD50 of the nerve agent C(+/-)P(+/-)-soman in these species to the same range as in...
7.
van Helden H, van der Wiel H, de Lange J, Busker R, Melchers B, Wolthuis O
Toxicol Appl Pharmacol
. 1992 Jul;
115(1):50-6.
PMID: 1631893
The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys. Five out of six marmosets, intoxicated with 5 x...
8.
DE JONG L, Benschop H, Due A, van Dijk C, Trap H, van der Wiel H, et al.
Life Sci
. 1992 Jan;
50(14):1057-62.
PMID: 1552824
Concentrations of C(+/-)P(+/-)-soman (1,2,2-trimethylpropyl methylphosphonofluoridate) in urine of anaesthetized, atropinized and artificially ventilated rats, guinea pigs and marmosets were determined 1-4 h after iv administration of 1-6 LD50 of the...
9.
Busker R, Zijlstra J, van der Wiel H, Melchers B, van Helden H
Toxicology
. 1991 Jan;
69(3):331-44.
PMID: 1658986
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses the organophosphorus compound crotylsarin (CRS),...
10.
van Helden H, van der Wiel H, Wolthuis O
J Pharm Pharmacol
. 1988 Jan;
40(1):35-41.
PMID: 2896771
Whether the temporary retention of intact soman in the rat and its subsequent delivery from tissues into the circulation of the blood is also demonstrable in guinea-pigs and marmosets has...