H C Isom
Overview
Explore the profile of H C Isom including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
582
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Recent Articles
1.
Bilello J, Cable E, MYERS R, Isom H
Gene Ther
. 2003 Apr;
10(9):733-49.
PMID: 12704412
Gene delivery to differentiated hepatocytes is notoriously difficult. Hepatocytes plated on collagen-coated dishes and maintained in dimethyl sulfoxide (DMSO)-supplemented medium acquire paracellular junctions, arrange themselves in multicellular islands and are...
2.
Bilello J, Delaney 4th W, Boyce F, Isom H
J Virol
. 2001 Sep;
75(20):9857-71.
PMID: 11559819
Baculovirus infection has extended the capabilities for transfection of exogenous genes into a variety of mammalian cell types. Because rat hepatocytes plated on collagen-coated dishes and maintained in dimethyl sulfoxide...
3.
Cable E, Miller T, Isom H
Arch Biochem Biophys
. 2001 May;
384(2):280-95.
PMID: 11368315
Regulation of delta-aminolevulinic acid (ALA) synthase and heme oxygenase was analyzed in primary rat hepatocytes and in two immortalized cell lines, CWSV16 and CWSV17 cells. ALA synthase was induced by...
4.
Delaney 4th W, Edwards R, Colledge D, Shaw T, Torresi J, Miller T, et al.
Antimicrob Agents Chemother
. 2001 May;
45(6):1705-13.
PMID: 11353615
Long-term nucleoside analog therapy for hepatitis B virus (HBV)-related disease frequently results in the selection of mutant HBV strains that are resistant to therapy. Molecular studies of such drug-resistant variants...
5.
Pan W, Devlin H, Kelley C, Isom H, Clawson G
RNA
. 2001 May;
7(4):610-21.
PMID: 11345439
Although ribozymes offer tremendous potential for posttranscriptionally controlling expression of targeted genes, their utility is often limited by the accessibility of the targeted regions within the RNA transcripts. Here we...
6.
Delaney 4th W, Miller T, Isom H
Antimicrob Agents Chemother
. 1999 Aug;
43(8):2017-26.
PMID: 10428929
(-)-Beta-2',3'-Dideoxy-3'-thiacytidine (lamivudine [3TC]) is a nucleoside analog which effectively interferes with the replication of hepatitis B virus (HBV) DNA in vitro and in vivo. We have investigated the antiviral properties...
7.
Cable E, Isom H
Drug Metab Dispos
. 1999 Feb;
27(2):255-60.
PMID: 9929512
3,5,5-Trimethylhexanoyl (TMH)-ferrocene has been used to produce iron loading in whole animals and in cultured hepatocytes. Iron loading produced by TMH-ferrocene is highly efficient and, of the compounds used to...
8.
Delaney 4th W, Isom H
Hepatology
. 1998 Oct;
28(4):1134-46.
PMID: 9755254
A novel transient mechanism for studying hepatitis B virus (HBV) gene expression and replication using recombinant HBV baculovirus to deliver the HBV genome to HepG2 cells was generated. In HBV...
9.
Cable E, Connor J, Isom H
Am J Pathol
. 1998 Mar;
152(3):781-92.
PMID: 9502420
We have previously shown that hepatocytes in long-term dimethylsulfoxide (DMSO) culture, fed a chemically defined medium, are highly differentiated and an excellent in vitro model of adult liver. Hepatocytes in...
10.
Cable E, Isom H
Hepatology
. 1997 Dec;
26(6):1444-57.
PMID: 9397984
We previously showed that primary rat hepatocytes plated on a rat-tail collagen coated dish and fed a chemically-defined medium supplemented with 2% dimethylsulfoxide (DMSO) can be maintained in a well-differentiated,...