Gurumoorthy Krishnamoorthy
Overview
Explore the profile of Gurumoorthy Krishnamoorthy including associated specialties, affiliations and a list of published articles.
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35
Citations
2815
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Recent Articles
1.
Archer D, Perez-Munoz M, Tollenaar S, Veniamin S, Hotte N, Cheng C, et al.
Cell Rep
. 2025 Feb;
44(3):115321.
PMID: 39985770
Limosilactobacillus reuteri is an immunomodulatory bacterium enriched in non-industrialized microbiomes, making it a therapeutic candidate for chronic diseases. However, effects of L. reuteri strains in mouse models of multiple sclerosis...
2.
Janakiraman M, Leliavski A, Varadarajulu J, Jenne D, Krishnamoorthy G
J Neuroinflammation
. 2023 Dec;
20(1):291.
PMID: 38057803
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T...
3.
Janakiraman M, Salei N, Krishnamoorthy G
Cancer Immunol Immunother
. 2022 Jul;
72(1):265-273.
PMID: 35802166
The gut microbiota has not only been implicated in the development of some cancers but has also been shown to modulate the efficacy of cancer therapeutics. Although the microbiota is...
4.
Janakiraman M, Na S, Krishnamoorthy G
PLoS One
. 2022 Apr;
17(4):e0266589.
PMID: 35385550
T cells express co-receptors CD4 and CD8, which are involved in the recognition of antigen presented to T cell receptors. The expression of CD4 in thymic hematopoietic cells is crucial...
5.
Na S, Krishnamoorthy G
Front Immunol
. 2021 Jun;
12:668487.
PMID: 34149706
There is a great interest in developing antigen-specific therapeutic approaches for the treatment of autoimmune diseases without compromising normal immune function. The key challenges are to control all antigen-specific lymphocyte...
6.
Lazarevic M, Djedovic N, Stanisavljevic S, Dimitrijevic M, Stegnjaic G, Krishnamoorthy G, et al.
J Neuroimmunol
. 2021 Mar;
354:577547.
PMID: 33765502
Experimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple...
7.
Na S, Janakiraman M, Leliavski A, Krishnamoorthy G
Proc Natl Acad Sci U S A
. 2021 Mar;
118(12).
PMID: 33723078
Sodium chloride, "salt," is an essential component of daily food and vitally contributes to the body's homeostasis. However, excessive salt intake has often been held responsible for numerous health risks...
8.
Jayavelu A, Schnoder T, Perner F, Herzog C, Meiler A, Krishnamoorthy G, et al.
Nature
. 2020 Nov;
588(7836):157-163.
PMID: 33239784
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system and in haematopoietic cancers....
9.
Faber H, Kurtoic D, Krishnamoorthy G, Weber P, Putz B, Muller-Myhsok B, et al.
Front Immunol
. 2020 Oct;
11:2165.
PMID: 33072080
Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited...
10.
Godel C, Kunkel B, Kashani A, Lassmann H, Arumugam M, Krishnamoorthy G
J Neuroinflammation
. 2020 Mar;
17(1):79.
PMID: 32143718
The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts currently...