Guoxian Yu
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Explore the profile of Guoxian Yu including associated specialties, affiliations and a list of published articles.
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Articles
70
Citations
466
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Recent Articles
1.
Liang X, Zhu Y, Bu Y, Dong M, Zhang G, Chen C, et al.
BMC Microbiol
. 2024 Dec;
24(1):541.
PMID: 39731043
Background: Smoking is a significant risk factor for pancreatic ductal adenocarcinoma (PDAC). This study aimed to investigate the effects of smoking on the pancreatic microbiome and metabolome in resectable and...
2.
Bu Y, Liang J, Li Z, Wang J, Wang J, Yu G
PLoS Comput Biol
. 2024 Dec;
20(12):e1012710.
PMID: 39724112
Diagnosing cancer subtypes is a prerequisite for precise treatment. Existing multi-omics data fusion-based diagnostic solutions build on the requisite of sufficient samples with complete multi-omics data, which is challenging to...
3.
Wang X, Xin B, Guo M, Yu G, Wang J
Fundam Res
. 2024 Dec;
4(4):761-769.
PMID: 39660349
The genome-wide association study (GWAS) aims to detect associations between individual single nucleotide polymorphisms (SNPs) or SNP interactions and phenotypes to decipher the genetic mechanism. Existing GWAS analysis tools have...
4.
Tan H, Guo M, Chen J, Wang J, Yu G
Nucleic Acids Res
. 2023 Dec;
52(3):e16.
PMID: 38088228
Functional molecular module (i.e., gene-miRNA co-modules and gene-miRNA-lncRNA triple-layer modules) analysis can dissect complex regulations underlying etiology or phenotypes. However, current module detection methods lack an appropriate usage and effective...
5.
Ma R, Li Q, Yu G, Wang J, Li Y, Xu X, et al.
Gut Pathog
. 2023 Sep;
15(1):45.
PMID: 37752551
Background: Patients with liver cirrhosis (LC) are prone to gastric mucosa damage. We investigated the alterations of gastric mucosa in LC patients and their possible mechanisms through multi-omics. Results: We...
6.
Ren L, Wang J, Li W, Guo M, Yu G
Brief Funct Genomics
. 2023 May;
23(2):128-137.
PMID: 37208992
Determining cell types by single-cell transcriptomics data is fundamental for downstream analysis. However, cell clustering and data imputation still face the computation challenges, due to the high dropout rate, sparsity...
7.
Liang J, Wang J, Yu G, Domeniconi C, Zhang X, Guo M
IEEE Trans Cybern
. 2023 Apr;
54(1):486-495.
PMID: 37022240
Finding the causal structure from a set of variables given observational data is a crucial task in many scientific areas. Most algorithms focus on discovering the global causal graph but...
8.
Wang J, Chen X, Wu Z, Guo M, Yu G
Brief Bioinform
. 2023 Mar;
24(3).
PMID: 37000166
Cooperative driver pathways discovery helps researchers to study the pathogenesis of cancer. However, most discovery methods mainly focus on genomics data, and neglect the known pathway information and other related...
9.
Ren L, Wang J, Li Z, Li Q, Yu G
Bioinformatics
. 2023 Mar;
39(4).
PMID: 36929930
Motivation: The integration of single-cell multi-omics data can uncover the underlying regulatory basis of diverse cell types and states. However, contemporary methods disregard the omics individuality, and the high noise,...
10.
Huang Z, Wang J, Lu X, Mohd Zain A, Yu G
Brief Bioinform
. 2023 Feb;
24(2).
PMID: 36733262
Single-cell RNA sequencing (scRNA-seq) data are typically with a large number of missing values, which often results in the loss of critical gene signaling information and seriously limit the downstream...