Guochun Liao
Overview
Explore the profile of Guochun Liao including associated specialties, affiliations and a list of published articles.
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23
Citations
1302
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Recent Articles
1.
Klumpp K, Lam A, Lukacs C, Vogel R, Ren S, Espiritu C, et al.
Proc Natl Acad Sci U S A
. 2015 Nov;
112(49):15196-201.
PMID: 26598693
The hepatitis B virus (HBV) core protein is essential for HBV replication and an important target for antiviral drug discovery. We report the first, to our knowledge, high-resolution crystal structure...
2.
H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load
Boon A, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, et al.
mBio
. 2011 Sep;
2(5).
PMID: 21896679
Unlabelled: The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly...
3.
Tregoning J, Yamaguchi Y, Wang B, Mihm D, Harker J, Bushell E, et al.
J Immunol
. 2010 Oct;
185(9):5384-91.
PMID: 20921522
Respiratory syncytial virus (RSV) is a major cause of respiratory morbidity, resulting in hospitalization for bronchiolitis in some infected infants that is associated with wheeze in later life. Genetic factors...
4.
Zheng M, Shafer S, Liao G, Liu H, Peltz G
Sci Transl Med
. 2010 Apr;
1(3):3ps4.
PMID: 20368166
Computational haplotype-based genetic mapping can be used to discover new biological mechanisms, disease-related pathways, and unexpected uses for existing drugs. Here we discuss the benefits and limitations of this methodology,...
5.
Liu H, Lu P, Guo Y, Farrell E, Zhang X, Zheng M, et al.
Genome Res
. 2009 Nov;
20(1):28-35.
PMID: 19923254
Acetaminophen-induced liver toxicity is the most frequent precipitating cause of acute liver failure and liver transplant, but contemporary medical practice has mainly focused on patient management after a liver injury...
6.
LaCroix-Fralish M, Mo G, Smith S, Sotocinal S, Ritchie J, Austin J, et al.
Pain
. 2009 May;
144(3):294-302.
PMID: 19464798
It is widely appreciated that there is significant inter-individual variability in pain sensitivity, yet only a handful of contributing genetic variants have been identified. Computational genetic mapping and quantitative trait...
7.
Chu L, Liang D, Li X, Sahbaie P, DArcy N, Liao G, et al.
Pharmacogenet Genomics
. 2009 Feb;
19(3):193-205.
PMID: 19214139
Objectives: Addiction to opioid narcotics represents a major public health challenge. Animal models of one component of addiction, physical dependence, show this trait to be highly heritable. The analysis of...
8.
Zaas A, Liao G, Chien J, Weinberg C, Shore D, Giles S, et al.
PLoS Genet
. 2008 Jun;
4(6):e1000101.
PMID: 18566672
Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been identified. However, genetic factors that...
9.
Liao G, Zhang X, Clark D, Peltz G
Drug Metab Rev
. 2008 May;
40(2):225-39.
PMID: 18464044
Utilization of pharmacogenomic information has the potential to significantly improve treatment outcome and markedly reduce the rate of attrition of drugs in clinical development. A major gap that limits our...
10.
Smith S, Marker C, Perry C, Liao G, Sotocinal S, Austin J, et al.
Pharmacogenet Genomics
. 2008 Feb;
18(3):231-41.
PMID: 18300945
Aims: Interindividual differences in analgesic drug response complicate the clinical management of pain. We aimed to identify genetic factors responsible for variable sensitivity to analgesic drugs of disparate neurochemical classes....