Guochun Gong
Overview
Explore the profile of Guochun Gong including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
736
Followers
0
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Recent Articles
1.
Kojak N, Kuno J, Fittipaldi K, Khan A, Wenger D, Glasser M, et al.
Nucleic Acids Res
. 2024 Apr;
52(10):5732-5755.
PMID: 38597682
Expansion of a G4C2 repeat in the C9orf72 gene is associated with familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). To investigate the underlying mechanisms of repeat instability, which...
2.
Montasser M, Van Hout C, Miloscio L, Howard A, Rosenberg A, Callaway M, et al.
Science
. 2021 Dec;
374(6572):1221-1227.
PMID: 34855475
Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are independent risk factors for cardiovascular disease. We identified associations between an Amish-enriched missense variant (p.Asn352Ser) in a functional domain...
3.
Hunt C, Hartford S, White D, Pefanis E, Hanna T, Herman C, et al.
Nat Commun
. 2021 May;
12(1):2770.
PMID: 33986266
CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of...
4.
Voronina V, Harris F, Schmahl J, Galligan C, Oristian D, Zamfirova R, et al.
Biol Reprod
. 2018 Oct;
100(3):686-696.
PMID: 30289441
The Adisintegrin and metalloprotease domain-containing (ADAM) family of proteins is involved in cell adhesion, migration, proteolysis, and signaling. Many ADAMs are required for reproduction; however, the role of Adam6 has...
5.
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee H, et al.
Sci Rep
. 2016 Mar;
6:23204.
PMID: 26979938
The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both the function of C9ORF72 and the...
6.
Lai K, Gong G, Atanasio A, Rojas J, Quispe J, Posca J, et al.
PLoS One
. 2015 Apr;
10(4):e0125522.
PMID: 25909911
In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal...
7.
Kuno J, Poueymirou W, Gong G, Siao C, Clarke G, Esau L, et al.
Transgenic Res
. 2014 Aug;
24(1):19-29.
PMID: 25087174
Known examples of male to female sex reversal in mice are caused by either strain incompatibilities or mutations in genes required for male sex determination. The resultant XY females are...
8.
Sauvageau M, Goff L, Lodato S, Bonev B, Groff A, Gerhardinger C, et al.
Elife
. 2014 Jan;
2:e01749.
PMID: 24381249
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional...
9.
Presicce G, Xu J, Gong G, Moreno J, Chaubal S, Xue F, et al.
Vet Med Int
. 2010 Oct;
2011.
PMID: 20885928
The aim of this study was to investigate the efficiency of in vitro embryo production in cattle utilizing sexed sperm from two bulls and oocytes recovered by OPU. Twenty donor...
10.
Gong G, Roach M, Jiang L, Yang X, Tian X
Cell Reprogram
. 2010 Aug;
12(2):151-60.
PMID: 20677930
The goals of the current study were to (1) improve culture conditions and (2) chemical passaging of bovine embryonic stem cell-like (bESC-like) cells. Specifically, the effects of human leukemia inhibitory...