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Guo-Sheng Hu

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Articles 19
Citations 315
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Recent Articles
1.
Hu G, Zheng Z, He Y, Wang D, Nie R, Nie R, et al.
Mol Cell Proteomics . 2025 Jan; 24(3):100919. PMID: 39884577
Understanding dysregulated genes and pathways in cancer is critical for precision oncology. Integrating mass spectrometry-based proteomic data with transcriptomic data presents unique opportunities for systematic analyses of dysregulated genes and...
2.
Wang X, Liu S, Hu G, Wang H, Zhang G, Cen X, et al.
Life Metab . 2025 Jan; 1(1):39-53. PMID: 39872690
Brown adipose tissue (BAT) plays a key role in thermogenesis during acute cold exposure. However, it remains unclear how BAT is prepared to rapidly turn on thermogenic genes. Here, we...
3.
Huang Q, Fan D, Zheng Z, Ran T, Bai A, Xiao R, et al.
J Med Chem . 2024 Apr; 67(8):6658-6672. PMID: 38569135
BRD4 is associated with a variety of human diseases, including breast cancer. The crucial roles of amino-terminal bromodomains (BDs) of BRD4 in binding with acetylated histones to regulate oncogene expression...
4.
Xue S, Cao S, Ding J, Li W, Hu G, Zheng J, et al.
Cell Mol Life Sci . 2024 Mar; 81(1):121. PMID: 38457049
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved in human cancers,...
5.
Cao S, Xue S, Li W, Hu G, Wu Z, Zheng J, et al.
Cell Death Discov . 2024 Mar; 10(1):110. PMID: 38431720
The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown....
6.
Li W, Huang Y, Lin Y, Zhang B, Li M, Zou Y, et al.
Cell Rep . 2023 Nov; 42(11):113385. PMID: 37938975
PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular mechanisms remain incompletely understood. Herein, we show that PRMT1 plays a critical role in RNA alternative splicing, with...
7.
Chen X, Ding J, Hu G, Shu X, Liu Y, Du J, et al.
Adv Sci (Weinh) . 2023 Jul; 10(25):e2206663. PMID: 37404090
Endocrine therapy is the frontline treatment for estrogen receptor (ER) positive breast cancer patients. However, the primary and acquired resistance to endocrine therapy drugs remain as a major challenge in...
8.
Yi J, Wang L, Hu G, Zhang Y, Du J, Ding J, et al.
EMBO J . 2023 Apr; 42(10):e112408. PMID: 37009655
The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and endocrine therapy resistance remain incompletely understood. Here, we report that circPVT1, a circular RNA generated from the lncRNA PVT1, is...
9.
Ding N, You A, Yang H, Hu G, Lai C, Liu W, et al.
Clin Cancer Res . 2023 Mar; 29(11):2095-2109. PMID: 36951687
Purpose: The oncogenic role of circular RNAs (circRNA) has been well studied in cancers including colorectal cancer. However, tumor-suppressive circRNAs and the mechanism through which they exert their antitumor effects...
10.
Xia L, Yuan L, Hu Y, Liu J, Hu G, Qi R, et al.
Cell Mol Immunol . 2023 Mar; 20(4):351-364. PMID: 36864189
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19) severity and lethality. However, drugs that are effective against inflammation to treat lethal...