Guillaume Gaud
Overview
Explore the profile of Guillaume Gaud including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
577
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Recent Articles
1.
Gaud G, Achar S, Bourassa F, Davies J, Hatzihristidis T, Choi S, et al.
Nat Immunol
. 2023 Dec;
25(3):579.
PMID: 38057618
No abstract available.
2.
Gaud G, Achar S, Bourassa F, Davies J, Hatzihristidis T, Choi S, et al.
Nat Immunol
. 2023 Nov;
24(12):2121-2134.
PMID: 37945821
The T cell antigen receptor (TCR) contains ten immunoreceptor tyrosine-based activation motif (ITAM) signaling sequences distributed within six CD3 subunits; however, the reason for such structural complexity and multiplicity is...
3.
Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Arya A, et al.
Sci Signal
. 2023 May;
16(784):eade1274.
PMID: 37159521
The T cell lineage-restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the...
4.
Choi S, Hatzihristidis T, Gaud G, Dutta A, Lee J, Arya A, et al.
J Exp Med
. 2023 Apr;
220(7).
PMID: 37067793
The T-lineage restricted protein THEMIS has been shown to play a critical role in T cell development. THEMIS, via its distinctive CABIT domains, inhibits the catalytic activity of the tyrosine...
5.
Weulersse M, Asrir A, Pichler A, Lemaitre L, Braun M, Carrie N, et al.
Immunity
. 2020 Oct;
53(4):824-839.e10.
PMID: 33053331
CD8 T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in...
6.
Gaud G, Roncagalli R, Chaoui K, Bernard I, Familiades J, Colacios C, et al.
Sci Signal
. 2018 Jul;
11(538).
PMID: 29991650
The activation of T cells requires the guanine nucleotide exchange factor VAV1. Using mice in which a tag for affinity purification was attached to endogenous VAV1 molecules, we analyzed by...
7.
Gaud G, Lesourne R, Love P
Nat Rev Immunol
. 2018 May;
18(8):485-497.
PMID: 29789755
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR...
8.
Kassem S, Gaud G, Bernard I, Benamar M, Dejean A, Liblau R, et al.
PLoS Genet
. 2016 Jul;
12(7):e1006185.
PMID: 27438086
The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic...
9.
Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, et al.
J Immunol
. 2015 Jul;
195(4):1608-16.
PMID: 26163585
The development of inflammatory diseases depends on complex interactions between several genes and various environmental factors. Discovering new genetic risk factors and understanding the mechanisms whereby they influence disease development...
10.
Saoudi A, Kassem S, Dejean A, Gaud G
Small GTPases
. 2014 May;
5.
PMID: 24825161
Rho-GTPases belong to the Ras superfamily and are crucial signal transducing proteins downstream of many receptors. In general, the Rho-GTPases function as molecular switches, cycling between inactive (GDP-bound) and active...