Guhan Nagappan
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Explore the profile of Guhan Nagappan including associated specialties, affiliations and a list of published articles.
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18
Citations
1246
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Recent Articles
1.
Thompson E, Spead O, Akerman S, Curcio C, Zaepfel B, Kent E, et al.
Acta Neuropathol Commun
. 2024 Dec;
12(1):203.
PMID: 39722074
The GC hexanucleotide repeat expansion in C9ORF72 is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse...
2.
Thompson E, Spead O, Akerman S, Curcio C, Zaepfel B, Kent E, et al.
Res Sq
. 2024 Dec;
PMID: 39711523
The GC hexanucleotide repeat expansion in the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models of...
3.
Thompson E, Spead O, Akerman S, Curcio C, Zaepfel B, Kent E, et al.
bioRxiv
. 2024 Sep;
PMID: 39253499
The GC hexanucleotide repeat expansion in is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models...
4.
Pang P, Nagappan G, Guo W, Lu B
NPJ Sci Learn
. 2019 Feb;
1:16003.
PMID: 30792890
Although late-phase long-term potentiation (L-LTP) is implicated in long-term memory, its molecular mechanisms are largely unknown. Here we provide evidence that L-LTP can be divided into two stages: an induction...
5.
Guo W, Nagappan G, Lu B
Dev Neurobiol
. 2018 Mar;
78(7):647-659.
PMID: 29575722
Brain-derived neurotrophic factor (BDNF) serves a pleiotropic role in the central nervous system, ranging from promoting neuronal survival and differentiation during development and synaptic modulation in the adult. An important,...
6.
Je H, Yang F, Ji Y, Potluri S, Fu X, Luo Z, et al.
J Neurosci
. 2013 Jun;
33(24):9957-62.
PMID: 23761891
During development, mammalian neuromuscular junctions (NMJs) transit from multiple-innervation to single-innervation through axonal competition via unknown molecular mechanisms. Previously, using an in vitro model system, we demonstrated that the postsynaptic...
7.
Lu B, Nagappan G, Guan X, Nathan P, Wren P
Nat Rev Neurosci
. 2013 May;
14(6):401-16.
PMID: 23674053
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis,...
8.
Howard L, Wyatt S, Nagappan G, Davies A
Development
. 2013 May;
140(10):2108-17.
PMID: 23633509
The somatosensory and sympathetic innervation of the vertebrate head is derived principally from the neurons of trigeminal and superior cervical ganglia (SCG), respectively. During development, the survival of both populations...
9.
Je H, Yang F, Ji Y, Nagappan G, Hempstead B, Lu B
Proc Natl Acad Sci U S A
. 2012 Sep;
109(39):15924-9.
PMID: 23019376
Formation of specific neuronal connections often involves competition between adjacent axons, leading to stabilization of the active terminal, while retraction of the less active ones. The underlying molecular mechanisms remain...
10.
Mei F, Nagappan G, Ke Y, Sacktor T, Lu B
PLoS One
. 2011 Jul;
6(6):e21568.
PMID: 21747912
Late-phase long term potentiation (L-LTP) is thought to be the cellular basis for long-term memory (LTM). While LTM as well as L-LTP is known to depend on transcription and translation,...