Guang-Xun Li
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Explore the profile of Guang-Xun Li including associated specialties, affiliations and a list of published articles.
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30
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555
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Recent Articles
1.
Huang H, Yuan Y, Wang W, Zhang S, Nie X, Yang W, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(4):e202415873.
PMID: 39496565
Sulfur-centered electrophilic 'warheads' have emerged as key components for chemical proteomic probes through sulfur-exchange chemistry (SuFEx) with protein nucleophiles. Among these functional groups, sulfonimidoyl fluorides (SIFs) stand out for their...
2.
Li L, Zhang S, Cui X, Zhao G, Tang Z, Li G
Org Lett
. 2024 Sep;
26(39):8371-8376.
PMID: 39316028
Enantioselective radical reactions mediated by TBADT have seldom been seen due to the inherent challenges. Herein, we disclose a new chiral hydrogen atom transfer (HAT) reagent that was generated easily...
3.
Yan M, Wang S, Zhang Y, Zhao J, Tang Z, Li G
Org Biomol Chem
. 2023 Dec;
22(2):348-352.
PMID: 38086690
Sulfinamides are a versatile class of compounds that find applications in both organic synthesis and pharmaceuticals. Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. Commercially...
4.
Xu Y, Yuan Y, Fu D, Fu Y, Zhou S, Yang W, et al.
Bioorg Med Chem
. 2023 May;
86:117299.
PMID: 37137271
RNA-binding proteins (RBPs) dysfunction has been implicated in a number of diseases, and RBPs have traditionally been considered to be undruggable targets. Here, targeted degradation of RBPs is achieved based...
5.
Chen Y, Fang D, Huang H, Nie X, Zhang S, Cui X, et al.
Org Lett
. 2023 Mar;
25(12):2134-2138.
PMID: 36939573
Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S-C bond formation rather than...
6.
Yang G, Huang H, Nie X, Zhang S, Cui X, Tang Z, et al.
J Org Chem
. 2023 Mar;
88(7):4581-4591.
PMID: 36926918
The sulfinamidines as aza analogues of sulfinamides received limited attention from both organic chemists and pharmaceutical chemists. Herein, we present a tandem oxidative/nucleophilic substitution approach for the synthesis of sulfinamidines...
7.
Yang G, Yuan Y, Tian Y, Zhang S, Cui X, Xia B, et al.
J Am Chem Soc
. 2023 Feb;
145(9):5439-5446.
PMID: 36811577
Direct construction of chiral S(VI) from prochiral S(II) is a formidable challenge due to the inevitable formation of stable chiral S(IV). Previous synthetic strategies rely on the conversion of chiral...
8.
Han M, Zhang S, Cui X, Wang Q, Li G, Tang Z
Angew Chem Int Ed Engl
. 2022 Mar;
61(22):e202201418.
PMID: 35301801
Described herein is the enantioselective synthesis of Hantzsch-type 1,4-dihydropyridines (DHPs), which are frequently contained in pharmaceuticals. Readily available symmetrical 1,4-DHPs were used as substrates, and the methyl group at the...
9.
Nie X, Chen Y, Zhang S, Cui X, Tang Z, Li G
Org Lett
. 2022 Mar;
24(10):2069-2074.
PMID: 35261250
Herein, we disclose a new catalytic asymmetric tandem reaction based on the Heyns rearrangement for the synthesis of chiral α-amino ketones with readily available substrates. The rearrangement is different from...
10.
Huang J, Chen J, Cui X, Zhao J, Tang Z, Li G
J Org Chem
. 2022 Feb;
87(5):3311-3318.
PMID: 35166530
Polysubstituted 1,2-dihydronaphthofurans were efficiently obtained in high yields and good diastereoselectivities with readily available substrates. The reaction proceeds smoothly via a series of tandem reactions, including Heyns rearrangement, oxidation, Friedel-Crafts...