Gregory Fettweis
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Explore the profile of Gregory Fettweis including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
277
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Recent Articles
1.
Fettweis G, Wagh K, Stavreva D, Jimenez-Panizo A, Kim S, Lion M, et al.
bioRxiv
. 2024 Dec;
PMID: 39713324
While the cohesin complex is a key player in genome architecture, how it localizes to specific chromatin sites is not understood. Recently, we and others have proposed that direct interactions...
2.
Johnson T, Fettweis G, Wagh K, Ceacero-Heras D, Krishnamurthy M, Sanchez de Medina F, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2413737121.
PMID: 39541347
The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There are indications that both receptors interact functionally and physically, but the precise...
3.
Fettweis G, Johnson T, Almeida-Prieto B, Weller-Perez J, Presman D, Hager G, et al.
Protein Sci
. 2023 Dec;
33(3):e4890.
PMID: 38160317
The prevailing model of steroid hormone nuclear receptor function assumes ligand-induced homodimer formation followed by binding to DNA hormone response elements (HREs). This model has been challenged by evidence showing...
4.
Wagh K, Stavreva D, Jensen R, Paakinaho V, Fettweis G, Schiltz R, et al.
Sci Adv
. 2023 Jun;
9(24):eade1122.
PMID: 37315128
How chromatin dynamics relate to transcriptional activity remains poorly understood. Using single-molecule tracking, coupled with machine learning, we show that histone H2B and multiple chromatin-bound transcriptional regulators display two distinct...
5.
Johnson T, Fettweis G, Wagh K, Almeida-Prieto B, Krishnamurthy M, Upadhyaya A, et al.
bioRxiv
. 2023 Feb;
PMID: 36789429
The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There are indications that both receptors interact functionally and physically, but the precise...
6.
Fettweis G, Johnson T, Almeida-Prieto B, Presman D, Hager G, Alvarez de la Rosa D
bioRxiv
. 2023 Feb;
PMID: 36789424
The prevailing model of steroid hormone nuclear receptor function assumes ligand-induced homodimer formation followed by binding to DNA hormone response elements (HREs). This model has been challenged by evidence showing...
7.
Jimenez-Panizo A, Alegre-Marti A, Tettey T, Fettweis G, Abella M, Anton R, et al.
Nucleic Acids Res
. 2022 Dec;
50(22):13063-13082.
PMID: 36464162
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have...
8.
Rinaldi L, Fettweis G, Kim S, Garcia D, Fujiwara S, Johnson T, et al.
Sci Adv
. 2022 Mar;
8(13):eabj8360.
PMID: 35353576
The cohesin complex is central to chromatin looping, but mechanisms by which these long-range chromatin interactions are formed and persist remain unclear. We demonstrate that interactions between a transcription factor...
9.
Garcia D, Fettweis G, Presman D, Paakinaho V, Jarzynski C, Upadhyaya A, et al.
Nucleic Acids Res
. 2021 Feb;
49(12):6605-6620.
PMID: 33592625
Single-molecule tracking (SMT) allows the study of transcription factor (TF) dynamics in the nucleus, giving important information regarding the diffusion and binding behavior of these proteins in the nuclear environment....
10.
Garcia D, Johnson T, Presman D, Fettweis G, Wagh K, Rinaldi L, et al.
Mol Cell
. 2021 Feb;
81(7):1484-1498.e6.
PMID: 33561389
Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs within the local chromatin context. The mechanisms by which TFs navigate the nuclear environment as they search for...