Gregg Siegal
Overview
Explore the profile of Gregg Siegal including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
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Articles
38
Citations
669
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Recent Articles
1.
Chen G, Wang Y, Zheng Z, Jiang W, Leppert A, Zhong X, et al.
Protein Sci
. 2024 Jun;
33(7):e5063.
PMID: 38864729
Proteins can misfold into fibrillar or amorphous aggregates and molecular chaperones act as crucial guardians against these undesirable processes. The BRICHOS chaperone domain, found in several otherwise unrelated proproteins that...
2.
Makraki E, Darby J, Carneiro M, Firth J, Heyam A, Ab E, et al.
Biochem J
. 2020 Oct;
477(22):4383-4395.
PMID: 33111951
A fragment screen of a library of 560 commercially available fragments using a kinetic assay identified a small molecule that increased the activity of the fungal glycoside hydrolase TrBgl2. An...
3.
Keiffer S, Carneiro M, Hollander J, Kobayashi M, Pogoryelev D, Ab E, et al.
J Biomol NMR
. 2020 Sep;
74(10-11):521-529.
PMID: 32901320
No matter the source of compounds, drug discovery campaigns focused directly on the target are entirely dependent on a consistent stream of reliable data that reports on how a putative...
4.
Makraki E, Carneiro M, Heyam A, Ab E, Siegal G, Hubbard R
Biomol NMR Assign
. 2020 Jul;
14(2):269.
PMID: 32654087
In the original publication of the article, the name of one of the authors is incorrect. The author's name is Eiso AB, but was modified to A. B. Eiso. The...
5.
Makraki E, Carneiro M, Heyam A, Eiso A, Siegal G, Hubbard R
Biomol NMR Assign
. 2020 Jun;
14(2):265-268.
PMID: 32562251
β-glucosidases have received considerable attention due to their essential role in bioethanol production from lignocellulosic biomass. β-glucosidase can hydrolyse cellobiose in cellulose degradation and its low activity has been considered...
6.
Siegal G, Selenko P
J Magn Reson
. 2019 Jul;
306:202-212.
PMID: 31358370
Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating cellular structures and their compositions. While in vivo and whole-cell NMR have a long tradition in cell-based approaches, high-resolution...
7.
Glas M, Ab E, Hollander J, Siegal G, Luirink J, de Esch I
Int J Mol Sci
. 2019 Jul;
20(15).
PMID: 31357624
The divisome is a large protein complex that regulates bacterial cell division and therefore represents an attractive target for novel antibacterial drugs. In this study, we report on the ligandability...
8.
Carneiro M, Ab E, Theisgen S, Siegal G
Essays Biochem
. 2017 Nov;
61(5):485-493.
PMID: 29118095
NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery,...
9.
Pritisanac I, Degiacomi M, Alderson T, Carneiro M, Ab E, Siegal G, et al.
J Am Chem Soc
. 2017 Jul;
139(28):9523-9533.
PMID: 28691806
Methyl groups are powerful probes for the analysis of structure, dynamics and function of supramolecular assemblies, using both solution- and solid-state NMR. Widespread application of the methodology has been limited...
10.
Chaikuad A, Lang S, Brennan P, Temperini C, Fedorov O, Hollander J, et al.
J Med Chem
. 2016 Jan;
59(4):1648-53.
PMID: 26731131
The P300/CBP-associated factor plays a central role in retroviral infection and cancer development, and the C-terminal bromodomain provides an opportunity for selective targeting. Here, we report several new classes of...