Grant R MacGregor
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Explore the profile of Grant R MacGregor including associated specialties, affiliations and a list of published articles.
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37
Citations
1885
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Recent Articles
1.
Generation of an Inducible Destabilized-Domain Cre Mouse Line to Target Disease Associated Microglia
Henningfield C, Ngo M, Murray K, Kwang N, Tsourmas K, Neumann J, et al.
Glia
. 2025 Feb;
PMID: 39988890
The function of microglia during progression of Alzheimer's disease (AD) can be investigated using mouse models that enable genetic manipulation of microglial subpopulations in a temporal manner. We developed mouse...
2.
Tran K, Kwang N, Butler C, Gomez-Arboledas A, Kawauchi S, Mar C, et al.
Mol Neurodegener
. 2025 Jan;
20(1):9.
PMID: 39844286
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to...
3.
Yardeni T, Olali A, Chen H, Wang L, Halton J, Zenab A, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2417252121.
PMID: 39752523
Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA-cancer association, we analyzed conplastic mice with...
4.
Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia
Henningfield C, Kwang N, Tsourmas K, Neumann J, Kawauchi S, Swarup V, et al.
bioRxiv
. 2024 Sep;
PMID: 39345513
Highlights: We developed a new mouse strain which specifically enables recombination of loxP sites in disease associated microglia (DAMs) and can be used to manipulate DAM-gene expression.DAMs represent a subset...
5.
Johnston K, Berackey B, Tran K, Gelber A, Yu Z, MacGregor G, et al.
Mol Psychiatry
. 2024 Aug;
30(2):461-477.
PMID: 39103533
The R47H missense mutation of the TREM2 gene is a known risk factor for development of Alzheimer's Disease. In this study, we analyze the impact of the Trem2 mutation on...
6.
Tran K, Kwang N, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, et al.
bioRxiv
. 2024 Jun;
PMID: 38895362
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to...
7.
Syage A, Pachow C, Murray K, Henningfield C, Fernandez K, Du A, et al.
J Neuroinflammation
. 2024 Jun;
21(1):157.
PMID: 38879499
Background: Cystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demyelination and enhancing remyelination in pre-clinical models of immune-mediated demyelination. How...
8.
Dunham S, Avelar-Barragan J, Rothman J, Adams E, Faraci G, Forner S, et al.
Alzheimers Dement
. 2024 Apr;
20(7):4935-4950.
PMID: 38572865
Introduction: Emerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome. Methods: We used shotgun metagenomics...
9.
Butler C, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, et al.
Alzheimers Dement
. 2024 Mar;
20(7):4914-4934.
PMID: 38506634
Background: Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD). Methods: CRISPR-Cas9 was used to generate...
10.
Garcia-Agudo L, Shi Z, Smith I, Kramar E, Tran K, Kawauchi S, et al.
Alzheimers Dement
. 2024 Mar;
20(4):2922-2942.
PMID: 38460121
Introduction: The BIN1 coding variant rs138047593 (K358R) is linked to Late-Onset Alzheimer's Disease (LOAD) via targeted exome sequencing. Methods: To elucidate the functional consequences of this rare coding variant on...