Andrea J Tenner
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Explore the profile of Andrea J Tenner including associated specialties, affiliations and a list of published articles.
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91
Citations
4625
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Recent Articles
1.
Tran K, Kwang N, Butler C, Gomez-Arboledas A, Kawauchi S, Mar C, et al.
Mol Neurodegener
. 2025 Jan;
20(1):9.
PMID: 39844286
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to...
2.
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, et al.
Nat Rev Immunol
. 2024 Dec;
PMID: 39653749
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines...
3.
Schartz N, Liang H, Carvalho K, Chu S, Mendoza-Arvilla A, Petrisko T, et al.
Nat Commun
. 2024 Aug;
15(1):7028.
PMID: 39147742
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a...
4.
Krattli R, Do A, El-Khatib S, Alikhani L, Markarian M, Vagadia A, et al.
bioRxiv
. 2024 Jul;
PMID: 39005286
Significance: Cranial radiotherapy for brain cancers activates CNS complement cascade, leading to cognitive decline. Ablation of the complement C5a/C5aR1 axis alleviates radiation-induced neuroinflammation, synaptic loss, and cognitive dysfunction, providing a...
5.
Tran K, Kwang N, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, et al.
bioRxiv
. 2024 Jun;
PMID: 38895362
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to...
6.
Dunham S, Avelar-Barragan J, Rothman J, Adams E, Faraci G, Forner S, et al.
Alzheimers Dement
. 2024 Apr;
20(7):4935-4950.
PMID: 38572865
Introduction: Emerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome. Methods: We used shotgun metagenomics...
7.
Butler C, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, et al.
Alzheimers Dement
. 2024 Mar;
20(7):4914-4934.
PMID: 38506634
Background: Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD). Methods: CRISPR-Cas9 was used to generate...
8.
Garcia-Agudo L, Shi Z, Smith I, Kramar E, Tran K, Kawauchi S, et al.
Alzheimers Dement
. 2024 Mar;
20(4):2922-2942.
PMID: 38460121
Introduction: The BIN1 coding variant rs138047593 (K358R) is linked to Late-Onset Alzheimer's Disease (LOAD) via targeted exome sequencing. Methods: To elucidate the functional consequences of this rare coding variant on...
9.
Soni N, Hohsfield L, Tran K, Kawauchi S, Walker A, Javonillo D, et al.
Alzheimers Dement
. 2024 Mar;
20(4):2794-2816.
PMID: 38426371
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity...
10.
C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease
Gomez-Arboledas A, Fonseca M, Kramar E, Chu S, Schartz N, Selvan P, et al.
Alzheimers Dement
. 2024 Jan;
20(3):2173-2190.
PMID: 38278523
Introduction: Synaptic loss is a hallmark of Alzheimer's disease (AD) that correlates with cognitive decline in AD patients. Complement-mediated synaptic pruning has been associated with this excessive loss of synapses...