Grant P Parnell
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Explore the profile of Grant P Parnell including associated specialties, affiliations and a list of published articles.
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27
Citations
795
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Recent Articles
1.
Afrasiabi A, Ahlenstiel C, Swaminathan S, Parnell G
Clin Transl Immunology
. 2023 Jun;
12(6):e1454.
PMID: 37337612
Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised by the demyelination of neurons in the central nervous system. Whilst it is unclear what precisely leads to MS, it...
2.
Keane J, Afrasiabi A, Schibeci S, Fewings N, Parnell G, Swaminathan S, et al.
Front Immunol
. 2021 Sep;
12:732694.
PMID: 34566997
Multiple Sclerosis (MS) is a complex immune-mediated disease of the central nervous system. Treatment is based on immunomodulation, including specifically targeting B cells. B cells are the main host for...
3.
Law S, Gatt P, Schibeci S, McKay F, Vucic S, Hart P, et al.
Genes Immun
. 2021 Jun;
22(4):227-233.
PMID: 34163021
Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this...
4.
Rhodes J, Botting R, Bertram K, Vine E, Rana H, Baharlou H, et al.
Nat Commun
. 2021 Apr;
12(1):2147.
PMID: 33846309
Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies...
5.
Afrasiabi A, Fewings N, Schibeci S, Keane J, Booth D, Parnell G, et al.
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33805769
Although the causes of Multiple Sclerosis (MS) still remain largely unknown, multiple lines of evidence suggest that (EBV) infection may contribute to the development of MS. Here, we aimed to...
6.
Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
Ong L, Schibeci S, Fewings N, Booth D, Parnell G
Epigenetics Chromatin
. 2021 Feb;
14(1):9.
PMID: 33541415
Background: The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect...
7.
Ong L, Booth D, Parnell G
Mol Nutr Food Res
. 2020 Oct;
64(23):e2000437.
PMID: 33079481
DNA methylation is increasingly being recognized as a mechanism through which environmental exposures confer disease risk. Several studies have examined the association between vitamin D and changes in DNA methylation...
8.
Ong L, Parnell G, Veale K, Stewart G, Liddle C, Booth D
Genes Immun
. 2020 Oct;
21(5):335-347.
PMID: 33037402
Multiple lines of evidence indicate Multiple Sclerosis (MS) is affected by vitamin D. This effect may be mediated by methylation in immune cell progenitors. We aimed to determine (1) if...
9.
Wijaya R, Read S, Truong N, Han S, Chen D, Shahidipour H, et al.
Gut
. 2020 Apr;
70(2):357-369.
PMID: 32229546
Objective: Vaccination against hepatitis B virus (HBV) confers protection from subsequent infection through immunological memory that is traditionally considered the domain of the adaptive immune system. This view has been...
10.
Afrasiabi A, Parnell G, Swaminathan S, Stewart G, Booth D
Sci Rep
. 2020 Jan;
10(1):193.
PMID: 31932685
Translating the findings of genome wide association studies (GWAS) to new therapies requires identification of the relevant immunological contexts to interrogate for genetic effects. In one of the largest GWAS,...