Graham T Holt
Overview
Explore the profile of Graham T Holt including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
754
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Holt G, Gorman J, Wang S, Lowegard A, Zhang B, Liu T, et al.
Cell Rep
. 2023 Jul;
42(7):112711.
PMID: 37436900
Broadly neutralizing antibodies (bNAbs) against HIV can reduce viral transmission in humans, but an effective therapeutic will require unusually high breadth and potency of neutralization. We employ the OSPREY computational...
2.
Wang S, Reeve S, Holt G, Ojewole A, Frenkel M, Gainza P, et al.
PLoS Comput Biol
. 2022 Feb;
18(2):e1009855.
PMID: 35143481
Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next...
3.
Lowegard A, Frenkel M, Holt G, Jou J, Ojewole A, Donald B
PLoS Comput Biol
. 2020 Jun;
16(6):e1007447.
PMID: 32511232
The K* algorithm provably approximates partition functions for a set of states (e.g., protein, ligand, and protein-ligand complex) to a user-specified accuracy ε. Often, reaching an ε-approximation for a particular...
4.
Jou J, Holt G, Lowegard A, Donald B
J Comput Biol
. 2019 Dec;
27(4):550-564.
PMID: 31855059
Protein design algorithms that model continuous sidechain flexibility and conformational ensembles better approximate the and behavior of proteins. The previous state of the art, iMinDEE-*-*, computes provable -approximations to partition...
5.
Holt G, Jou J, Gill N, Lowegard A, Martin J, Madden D, et al.
J Phys Chem B
. 2019 Nov;
123(49):10441-10455.
PMID: 31697075
The CFTR-associated ligand PDZ domain (CALP) binds to the cystic fibrosis transmembrane conductance regulator (CFTR) and mediates lysosomal degradation of mature CFTR. Inhibition of this interaction has been explored as...
6.
Reeve S, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, et al.
ACS Infect Dis
. 2019 Oct;
5(11):1896-1906.
PMID: 31565920
The spread of plasmid borne resistance enzymes in clinical isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds...
7.
Hallen M, Martin J, Ojewole A, Jou J, Lowegard A, Frenkel M, et al.
J Comput Chem
. 2018 Oct;
39(30):2494-2507.
PMID: 30368845
We present osprey 3.0, a new and greatly improved release of the osprey protein design software. Osprey 3.0 features a convenient new Python interface, which greatly improves its ease of...
8.
de Juan-Sanz J, Holt G, Schreiter E, de Juan F, Kim D, Ryan T
Neuron
. 2017 Feb;
93(4):867-881.e6.
PMID: 28162809
Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is poorly understood. We developed novel genetically...
9.
Dana H, Mohar B, Sun Y, Narayan S, Gordus A, Hasseman J, et al.
Elife
. 2016 Mar;
5.
PMID: 27011354
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large populations of neurons and in small neuronal compartments, over times of milliseconds to months. Although GFP-based GECIs are widely...
10.
Henderson M, Baldwin H, Werley C, Boccardo S, Whitaker L, Yan X, et al.
PLoS One
. 2015 Oct;
10(10):e0139273.
PMID: 26451944
Endoplasmic reticulum calcium homeostasis is critical for cellular functions and is disrupted in diverse pathologies including neurodegeneration and cardiovascular disease. Owing to the high concentration of calcium within the ER,...