Grace M Scheidemantle
Overview
Explore the profile of Grace M Scheidemantle including associated specialties, affiliations and a list of published articles.
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4
Citations
6
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Recent Articles
1.
DIppolito R, Scheidemantle G, Rabara D, Abreu Blanco M, Ramakrishnan N, Widmeyer S, et al.
Methods Mol Biol
. 2024 Jul;
2823:291-310.
PMID: 39052227
We present a novel method to determine engagement and specificity of KRAS4B-targeting compounds in vitro. By employing top-down mass spectrometry (MS), which analyzes intact and modified protein molecules (proteoforms), we...
2.
DIppolito R, Scheidemantle G, Smith B, Powell K, Eury S, Neish A, et al.
Methods Mol Biol
. 2024 Apr;
2797:299-322.
PMID: 38570469
Prior analysis of intact and modified protein forms (proteoforms) of KRAS4B isolated from cell lines and tumor samples by top-down mass spectrometry revealed the presence of novel posttranslational modifications (PTMs)...
3.
DIppolito R, Rabara D, Abreu Blanco M, Alberico E, Drew M, Ramakrishnan N, et al.
Anal Chem
. 2024 Mar;
96(13):5223-5231.
PMID: 38498381
Development of new targeted inhibitors for oncogenic KRAS mutants may benefit from insight into how a given mutation influences the accessibility of protein residues and how compounds interact with mutant...
4.
Dorweiler J, Obaoye J, Oddo M, Shilati F, Scheidemantle G, Coleman T, et al.
PLoS One
. 2020 Mar;
15(3):e0229796.
PMID: 32134970
Chaperones and autophagy are components of the protein quality control system that contribute to the management of proteins that are misfolded and aggregated. Here, we use yeast prions, which are...