Gordon D Lowe
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Explore the profile of Gordon D Lowe including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
700
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Recent Articles
1.
de Vries P, Sabater-Lleal M, Chasman D, Trompet S, Ahluwalia T, Teumer A, et al.
PLoS One
. 2017 Jan;
12(1):e0167742.
PMID: 28107422
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead...
2.
Wannamethee S, Whincup P, Papacosta O, Lennon L, Lowe G
Int J Cardiol
. 2017 Jan;
230:567-571.
PMID: 28043678
Aims: Chronic heart failure (HF) is associated with activation of blood coagulation but there is a lack of prospective studies on the association between coagulation markers and incident HF in...
3.
Herder C, Faerch K, Carstensen-Kirberg M, Lowe G, Haapakoski R, Witte D, et al.
Eur J Endocrinol
. 2016 Aug;
175(5):367-77.
PMID: 27491375
Objective: Higher systemic levels of pro-inflammatory biomarkers and low adiponectin are associated with increased risk of type 2 diabetes, but their associations with changes in glycaemic deterioration before onset of...
4.
de Vries P, Chasman D, Sabater-Lleal M, Chen M, Huffman J, Steri M, et al.
Hum Mol Genet
. 2015 Nov;
25(2):358-70.
PMID: 26561523
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better...
5.
Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu A, et al.
PLoS One
. 2015 Jan;
9(12):e111156.
PMID: 25551457
Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association...
6.
Loeffen R, Winckers K, Ford I, Jukema J, Robertson M, Stott D, et al.
J Gerontol A Biol Sci Med Sci
. 2014 Dec;
70(8):982-8.
PMID: 25540034
Background: Hypercoagulability may be an important contributor to the pathophysiology of atherosclerosis and atherothrombosis. As thrombin fulfills a central role in coagulation and links to several cellular mechanisms involved in...
7.
Wannamethee S, Whincup P, Lennon L, Papacosta O, Lowe G
J Am Geriatr Soc
. 2014 Dec;
62(12):2357-62.
PMID: 25516032
Objectives: To examine the independent relationships between fibrin D-dimer, interleukin 6 (IL-6), C-reactive protein (CRP), and fibrinogen and incident mobility limitation and mortality. Design: Prospective. Setting: General practice in 24...
8.
Huang J, Huffman J, Yamakuchi M, Yamkauchi M, Trompet S, Asselbergs F, et al.
Arterioscler Thromb Vasc Biol
. 2014 Mar;
34(5):1093-101.
PMID: 24578379
Objective: Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA...
9.
Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson A, et al.
Circulation
. 2013 Aug;
128(12):1310-24.
PMID: 23969696
Background: Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain...
10.
Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease?
Hingorani A, Sofat R, Morris R, Whincup P, Lowe G, Mindell J, et al.
Eur Heart J
. 2012 Jul;
33(18):2258-64.
PMID: 22766581
No abstract available.