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Goran Engberg

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Articles 59
Citations 1524
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Recent Articles
11.
Gracias J, Orhan F, Horbeck E, Holmen-Larsson J, Khanlarkani N, Malwade S, et al.
Nat Commun . 2022 Nov; 13(1):6427. PMID: 36329007
Postsynaptic density is reduced in schizophrenia, and risk variants increasing complement component 4A (C4A) gene expression are linked to excessive synapse elimination. In two independent cohorts, we show that cerebrospinal...
12.
Shang P, Ho A, Tufvesson-Alm M, Lindberg D, Grant C, Orhan F, et al.
Transl Psychiatry . 2022 Jun; 12(1):229. PMID: 35665740
Psychotic disorders are currently diagnosed by examining the patient's mental state and medical history. Identifying reliable diagnostic, monitoring, predictive, or prognostic biomarkers would be useful in clinical settings and help...
13.
Matlik K, Garton D, Montano-Rodriguez A, Olfat S, Eren F, Casserly L, et al.
Mol Psychiatry . 2022 May; 27(8):3247-3261. PMID: 35618883
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that increased expression of endogenous GDNF could induce...
14.
Sellgren C, Imbeault S, Larsson M, Oliveros A, Nilsson I, Codeluppi S, et al.
Mol Psychiatry . 2021 Nov; 27(3):1855. PMID: 34744164
No abstract available.
15.
Imbeault S, Gubert Olive M, Jungholm O, Erhardt S, Wigstrom H, Engberg G, et al.
Int J Tryptophan Res . 2021 Sep; 14:11786469211041368. PMID: 34483669
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice...
16.
Sellgren C, Imbeault S, Larsson M, Oliveros A, Nilsson I, Codeluppi S, et al.
Mol Psychiatry . 2021 May; 26(11):6820-6832. PMID: 33976392
The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are...
17.
Tufvesson-Alm M, Imbeault S, Liu X, Zheng Y, Faka A, Choi D, et al.
J Neuroimmunol . 2020 Oct; 349:577401. PMID: 33002724
Immune activation contributes to the pathophysiology of psychiatric disorders. Administration of a single dose of lipopolysaccharides (LPS) has been shown to induce depressive- and anxiety-like behaviors in rodents through activation...
18.
Xu C, Sellgren C, Fatouros-Bergman H, Piehl F, Blennow K, Zetterberg H, et al.
IBRO Rep . 2020 Jun; 8:136-142. PMID: 32490278
Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and modeling using patient-derived cells...
19.
Howner K, Andine P, Engberg G, Ekstrom E, Lindstrom E, Nilsson M, et al.
Front Psychiatry . 2020 Feb; 10:963. PMID: 32009993
Pharmacological treatment is of great importance in forensic psychiatry, and the vast majority of patients are treated with antipsychotic agents. There are several systematic differences between general and forensic psychiatric...
20.
Peyton L, Oliveros A, Tufvesson-Alm M, Schwieler L, Starski P, Engberg G, et al.
Int J Tryptophan Res . 2020 Jan; 12:1178646919891169. PMID: 31896932
Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of -methyl-d-aspartate (NMDA) receptors. Kynurenic acid levels...