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Sophie Erhardt

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Recent Articles
1.
Ahlberg Weidenfors J, Griska V, Li X, Pranckeviciene A, Pakalniene J, Atlas A, et al.
Brain Behav Immun . 2025 Feb; 125:452-465. PMID: 39904470
Background: Tick-borne encephalitis (TBE) patients frequently suffer cognitive and neuropsychiatric sequelae, which may be severe and long-lasting. The underlying mechanisms remain poorly understood, but likely involve dysregulation of immunological and...
2.
Wallin H, Jansson E, Erhardt S, Wallquist C, Hylander B, Jacobson S, et al.
PLoS One . 2025 Jan; 20(1):e0317201. PMID: 39813270
Background: The causes of reduced aerobic exercise capacity (ExCap) in chronic kidney disease (CKD) are multifactorial, possibly involving the accumulation of tryptophan (TRP) metabolites such as kynurenine (KYN) and kynurenic...
3.
Li X, Eden A, Malwade S, Cunningham J, Bergquist J, Ahlberg Weidenfors J, et al.
Brain Behav Immun . 2024 Nov; 124():163-176. PMID: 39615604
Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 2019 (COVID-19). Metabolites of the kynurenine pathway have been proposed to account...
4.
Pocivavsek A, Schwarcz R, Erhardt S
Pharmacol Rev . 2024 Sep; 76(6):978-1008. PMID: 39304346
Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in...
5.
Sathyasaikumar K, Blanco-Ayala T, Zheng Y, Schwieler L, Erhardt S, Tufvesson-Alm M, et al.
Int J Tryptophan Res . 2024 Jun; 17:11786469241262876. PMID: 38911967
Alterations in the composition of the gut microbiota may be causally associated with several brain diseases. Indole-3-propionic acid (IPrA) is a tryptophan-derived metabolite, which is produced by intestinal commensal microbes,...
6.
Kamandulis S, Lukonaitiene I, Snieckus A, Brazaitis M, Mickevicius M, Cernych M, et al.
Med Sci Sports Exerc . 2024 Jun; 56(10):2007-2015. PMID: 38857520
Purpose: To monitor changes in mood, cognitive function, brain electrical activity, and circulating kynurenine pathway metabolites in response to a 3-wk severe physical activity (PA) restriction, followed by 3 wk...
7.
Louvrou V, Solianik R, Brazaitis M, Erhardt S
Eur J Clin Nutr . 2024 May; 78(8):677-683. PMID: 38789718
Background/objectives: Prolonged fasting triggers a stress response within the human body. Our objective was to investigate the impact of prolonged fasting, in conjunction with stress, on kynurenine pathway metabolites. Subjects/methods:...
8.
Lee M, Cernvall M, Borg J, Plaven-Sigray P, Larsson C, Erhardt S, et al.
JAMA Psychiatry . 2024 Feb; 81(5):468-476. PMID: 38416480
Importance: Cognitive impairment contributes significantly to clinical outcome and level of function in individuals with psychotic disorders. These impairments are present already at psychosis onset at a group level; however,...
9.
Haroon H, Ho A, Gupta V, Dasari S, Sellgren C, Cervenka S, et al.
J Psychiatr Res . 2024 Feb; 171:306-315. PMID: 38340697
Apart from their diagnostic, monitoring, or prognostic utility in clinical settings, molecular biomarkers may be instrumental in understanding the pathophysiology of psychiatric disorders, including schizophrenia. Using untargeted metabolomics, we recently...
10.
Koskuvi M, Malwade S, Gracias Lekander J, Horbeck E, Bruno S, Holmen Larsson J, et al.
Brain Behav Immun . 2024 Feb; 117:313-319. PMID: 38301948
Recent evidence has implicated complement component (C) 4A in excessive elimination of synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal through signaling within the C1q initiated...