Gopinath Krishnan
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Explore the profile of Gopinath Krishnan including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
450
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Recent Articles
1.
Dong D, Zhang Z, Li Y, Latallo M, Wang S, Nelson B, et al.
Sci Signal
. 2024 Aug;
17(848):eadl1030.
PMID: 39106320
Hexanucleotide repeat expansion in the gene is the most frequent inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansion results in multiple dipeptide repeat proteins, among...
2.
Halim D, Krishnan G, Hass E, Lee S, Verma M, Almeida S, et al.
Cell Rep
. 2024 Jun;
43(7):114375.
PMID: 38935506
GGGGCC (GC) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely...
3.
Martin E, Santacruz C, Mitevska A, Jones I, Krishnan G, Gao F, et al.
bioRxiv
. 2024 Apr;
PMID: 38585915
A hexanucleotide repeat expansion (HRE) in is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, patients with the HRE exhibit a wide disparity...
4.
Sonobe Y, Lee S, Krishnan G, Gu Y, Kwon D, Gao F, et al.
Elife
. 2023 Sep;
12.
PMID: 37675986
A hexanucleotide repeat expansion in is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide...
5.
Lee S, Jun Y, Linares G, Butler B, Yuva-Adyemir Y, Moore J, et al.
Neuron
. 2023 Mar;
111(9):1381-1390.e6.
PMID: 36931278
GGGGCC repeat expansion in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat RNAs can be translated into dipeptide repeat...
6.
Hung S, Linares G, Chang W, Eoh Y, Krishnan G, Mendonca S, et al.
Cell
. 2023 Feb;
186(4):786-802.e28.
PMID: 36754049
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes. Although therapeutics specifically targeting known causal mutations may rescue individual types of ALS, these...
7.
Chen Y, Krishnan G, Parsi S, Pons M, Nikolaki V, Cao L, et al.
Acta Neuropathol Commun
. 2022 Nov;
10(1):169.
PMID: 36414997
Chromosome 3-linked frontotemporal dementia (FTD3) is caused by a gain-of-function mutation in CHMP2B, resulting in the production of a truncated toxic protein, CHMP2B. Loss-of-function mutations in spastin are the most...
8.
Meijboom K, Abdallah A, Fordham N, Nagase H, Rodriguez T, Kraus C, et al.
Nat Commun
. 2022 Oct;
13(1):6286.
PMID: 36271076
A GGGGCC hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), fatal neurodegenerative diseases with no...
9.
Krishnan G, Raitcheva D, Bartlett D, Prudencio M, McKenna-Yasek D, Douthwright C, et al.
Nat Commun
. 2022 May;
13(1):2799.
PMID: 35589711
GGGGCC repeat expansion in C9ORF72, which can be translated in both sense and antisense directions into five dipeptide repeat (DPR) proteins, including poly(GP), poly(GR), and poly(GA), is the most common...
10.
Sonobe Y, Aburas J, Krishnan G, Fleming A, Ghadge G, Islam P, et al.
Nat Commun
. 2021 Oct;
12(1):6025.
PMID: 34654821
A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs)...