Glenn Merlino
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Explore the profile of Glenn Merlino including associated specialties, affiliations and a list of published articles.
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134
Citations
5347
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Recent Articles
1.
Hirsch M, Pal S, Rashidi Mehrabadi F, Malikic S, Gruen C, Sassano A, et al.
Cell Syst
. 2024 Dec;
16(1):101156.
PMID: 39701099
Cancer progression is an evolutionary process driven by the selection of cells adapted to gain growth advantage. We present a formal study on the adaptation of gene expression in subclonal...
2.
Daugherty-Lopes A, Perez-Guijarro E, Gopalan V, Rappaport J, Chen Q, Huang A, et al.
bioRxiv
. 2024 Oct;
PMID: 39372744
Despite the promising results of immune checkpoint blockade (ICB) therapy, outcomes for patients with brain metastasis (BrM) remain poor. Identifying resistance mechanisms has been hindered by limited access to patient...
3.
Isaak A, Clements G, Buenaventura R, Merlino G, Yu Y
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38732242
Melanoma is the most severe and fatal form of skin cancer, resulting from multiple gene mutations with high intra-tumor and inter-tumor molecular heterogeneity. Treatment options for patients whose disease has...
4.
Hirsch M, Pal S, Rashidi Mehrabadi F, Malikic S, Gruen C, Sassano A, et al.
bioRxiv
. 2024 May;
PMID: 38712152
Cancer progression is an evolutionary process driven by the selection of cells adapted to gain growth advantage. We present the first formal study on the adaptation of gene expression in...
5.
Kizilkale C, Rashidi Mehrabadi F, Sadeqi Azer E, Perez-Guijarro E, Marie K, Lee M, et al.
Nat Comput Sci
. 2024 Jan;
2(9):577-583.
PMID: 38177468
We introduce HUNTRESS, a computational method for mutational intratumor heterogeneity inference from noisy genotype matrices derived from single-cell sequencing data, the running time of which is linear with the number...
6.
Hibler W, Merlino G, Yu Y
Cells
. 2023 Dec;
12(23).
PMID: 38067178
Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic...
7.
Buenaventura R, Merlino G, Yu Y
Cells
. 2023 Jun;
12(12).
PMID: 37371090
Ezrin is the cytoskeletal organizer and functions in the modulation of membrane-cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell-cell adhesion and movement, as well as cell...
8.
Gruen C, Yang H, Sassano A, Wu E, Gopalan V, Marie K, et al.
bioRxiv
. 2023 Jun;
PMID: 37333132
Intratumoral heterogeneity (ITH) can promote cancer progression and treatment failure, but the complexity of the regulatory programs and contextual factors involved complicates its study. To understand the specific contribution of...
9.
Yu Y, Mendoza A, Merlino G
STAR Protoc
. 2023 Jun;
4(3):102349.
PMID: 37314923
Metastasis, a complex process, is responsible for most deaths in patients with cancer. Clinically relevant research models are indispensable to advancing our understanding of metastatic mechanisms and developing new treatments....
10.
Grafanaki K, Grammatikakis I, Ghosh A, Gopalan V, Olgun G, Liu H, et al.
Pharmacol Ther
. 2023 Jun;
248:108466.
PMID: 37301330
Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention. Studies have identified that...