Giusy Tassone
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Explore the profile of Giusy Tassone including associated specialties, affiliations and a list of published articles.
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26
Citations
111
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Recent Articles
1.
Tassone G, Maramai S, Paolino M, Lamponi S, Poggialini F, Dreassi E, et al.
Sci Rep
. 2024 Sep;
14(1):22514.
PMID: 39341955
Bioconjugation is one of the most promising strategies to improve drug delivery, especially in cancer therapy. Biomolecules such as bile acids (BAs) have been intensively explored as carriers, due to...
2.
Tassone G, Pozzi C, Mangani S
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125848
Glutaminyl-peptide cyclotransferases (QCs) convert the N-terminal glutamine or glutamate residues of protein and peptide substrates into pyroglutamate (pE) by releasing ammonia or a water molecule. The N-terminal pE modification protects...
3.
Saletti M, Paolino M, Venditti J, Bonechi C, Giuliani G, Lamponi S, et al.
Chembiochem
. 2024 Feb;
25(8):e202300862.
PMID: 38369609
A Morita-Baylis-Hillman Adduct (MBHA) derivative bearing a triphenylamine moiety was found to react with human serum albumin (HSA) shifting its emission from the blue to the green-yellow thus leading to...
4.
Linciano P, Pozzi C, Tassone G, Landi G, Mangani S, Santucci M, et al.
Eur J Med Chem
. 2023 Dec;
264:115946.
PMID: 38043491
Pteridine reductase 1 (PTR1) is a catalytic protein belonging to the folate metabolic pathway in Trypanosmatidic parasites. PTR1 is a known target for the medicinal chemistry development of antiparasitic agents...
5.
Pozzi C, Vanet A, Francesconi V, Tagliazucchi L, Tassone G, Venturelli A, et al.
J Med Chem
. 2023 Mar;
66(6):3664-3702.
PMID: 36857133
The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main protease, Spike protein, and RNA polymerase), compared with proteins of other human pathogenic coronaviruses, may have a short-lasting clinical efficacy....
6.
Legru A, Verdirosa F, Vo-Hoang Y, Tassone G, Vascon F, Thomas C, et al.
J Med Chem
. 2022 Nov;
65(24):16392-16419.
PMID: 36450011
Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. Here, we describe...
7.
Palomba T, Tassone G, Vacca C, Bartalucci M, Valeri A, Pozzi C, et al.
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430693
The field of targeted protein degradation, through the control of the ubiquitin-proteasome system (UPS), is progressing considerably; to exploit this new therapeutic modality, the proteolysis targeting chimera (PROTAC) technology was...
8.
Tassone G, Mazzorana M, Pozzi C
Pharmaceuticals (Basel)
. 2022 Nov;
15(11).
PMID: 36355513
Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects,...
9.
Barbera S, Raucci L, Tassone G, Tinti L, Prischi F, Santucci A, et al.
Int J Biol Macromol
. 2022 Oct;
224:453-464.
PMID: 36265539
Blocking the signaling activated by the plasma membrane receptor CD93 has recently been demonstrated a useful tool in antiangiogenic treatment and oncotherapy. In the proliferating endothelium, CD93 regulates cell adhesion,...
10.
Tassone G, Mazzorana M, Mangani S, Petricci E, Cini E, Giannini G, et al.
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012721
Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that stabilizes client proteins in a folded and functional state. It is composed of two identical and symmetrical subunits and...