Gisela A Kuhn
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Explore the profile of Gisela A Kuhn including associated specialties, affiliations and a list of published articles.
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33
Citations
756
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Recent Articles
11.
Paul G, Vallaster P, Ruegg M, Scheuren A, Tourolle D, Kuhn G, et al.
Front Cell Dev Biol
. 2022 Jun;
10:856204.
PMID: 35686050
Bone healing and remodeling are mechanically driven processes. While the generalized response to mechanical stimulation in bone is well-understood, much less is known about the mechanobiology-regulating tissue-scale bone formation and...
12.
Wehrle E, Paul G, Tourolle Ne Betts D, Kuhn G, Muller R
Sci Rep
. 2021 Nov;
11(1):23037.
PMID: 34845246
Fracture healing is regulated by mechanical loading. Understanding the underlying mechanisms during the different healing phases is required for targeted mechanical intervention therapies. Here, the influence of individualized cyclic mechanical...
13.
Paul G, Wehrle E, Tourolle D, Kuhn G, Muller R
Sci Rep
. 2021 Jun;
11(1):13511.
PMID: 34188165
Mechanical loading allows both investigation into the mechano-regulation of fracture healing as well as interventions to improve fracture-healing outcomes such as delayed healing or non-unions. However, loading is seldom individualised...
14.
Wehrle E, Tourolle Ne Betts D, Kuhn G, Floreani E, Nambiar M, Schroeder B, et al.
Sci Rep
. 2021 Apr;
11(1):8660.
PMID: 33883593
Thorough preclinical evaluation of functionalized biomaterials for treatment of large bone defects is essential prior to clinical application. Using in vivo micro-computed tomography (micro-CT) and mouse femoral defect models with...
15.
Malhotra A, Walle M, Paul G, Kuhn G, Muller R
Sci Rep
. 2021 Jan;
11(1):1861.
PMID: 33479260
Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone...
16.
Scheuren A, Vallaster P, Kuhn G, Paul G, Malhotra A, Kameo Y, et al.
Front Bioeng Biotechnol
. 2020 Nov;
8:566346.
PMID: 33154964
It is well-established that cyclic, but not static, mechanical loading has anabolic effects on bone. However, the function describing the relationship between the loading frequency and the amount of bone...
17.
Scheuren A, Kuhn G, Muller R
PLoS One
. 2020 Sep;
15(9):e0239534.
PMID: 32966306
In vivo micro-CT has already been used to monitor microstructural changes of bone in mice of different ages and in models of age-related diseases such as osteoporosis. However, as aging...
18.
Wuertz-Kozak K, Roszkowski M, Cambria E, Block A, Kuhn G, Abele T, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32927845
Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early...
19.
Scheuren A, DHulst G, Kuhn G, Masschelein E, Wehrle E, De Bock K, et al.
J Cachexia Sarcopenia Muscle
. 2020 Jun;
11(4):1121-1140.
PMID: 32596975
Background: Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia....
20.
Julier Z, Karami R, Nayer B, Lu Y, Park A, Maruyama K, et al.
Sci Adv
. 2020 Jun;
6(24):eaba7602.
PMID: 32582857
Although growth factors (GFs) are key molecules for regenerative medicine, their use has been limited by issues associated with suboptimal delivery systems and incomplete understanding of their signaling dynamics. Here,...