Gisela A Kuhn
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Explore the profile of Gisela A Kuhn including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
756
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Recent Articles
21.
SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy
Ni R, Zarb Y, Kuhn G, Muller R, Yundung Y, Nitsch R, et al.
MAGMA
. 2020 May;
33(6):769-781.
PMID: 32468149
Objective: Brain calcifications are associated with several neurodegenerative diseases. Here, we describe the occurrence of intracranial calcifications as a new phenotype in transgenic P301L mice overexpressing four repeat tau, a...
22.
Tourolle Ne Betts D, Wehrle E, Paul G, Kuhn G, Christen P, Hofmann S, et al.
Sci Rep
. 2020 Jan;
10(1):1100.
PMID: 31980656
An improved understanding of how local mechanical stimuli guide the fracture healing process has the potential to enhance clinical treatment of bone injury. Recent preclinical studies of bone defect in...
23.
Wehrle E, Tourolle Ne Betts D, Kuhn G, Scheuren A, Hofmann S, Muller R
Sci Rep
. 2019 Nov;
9(1):17445.
PMID: 31768003
Longitudinal in vivo micro-computed tomography (micro-CT) is of interest to non-invasively capture the healing process of individual animals in preclinical fracture healing studies. However, it is not known whether longitudinal...
24.
Mochizuki M, Guc E, Park A, Julier Z, Briquez P, Kuhn G, et al.
Nat Biomed Eng
. 2019 Nov;
4(4):463-475.
PMID: 31685999
Growth factors can stimulate tissue regeneration, but the side effects and low effectiveness associated with suboptimal delivery systems have impeded their use in translational regenerative medicine. Physiologically, growth factor interactions...
25.
Artsi H, Gurt I, El-Haj M, Muller R, Kuhn G, Ben Shalom G, et al.
Front Endocrinol (Lausanne)
. 2019 Mar;
10:126.
PMID: 30873124
Bone marrow adipose tissue (MAT) is influenced by nutritional cues, and participates in whole body energy metabolism. To investigate the role of Sirtuin1 (Sirt1), a key player in metabolism, in...
26.
Badilatti S, Kuhn G, Ferguson S, Muller R
J Orthop Translat
. 2018 Jul;
3(4):185-196.
PMID: 30035057
Computational models are gaining importance not only for basic science, but also for the analysis of clinical interventions and to support clinicians prior to intervention. Vertebroplasty has been used to...
27.
Filliat G, Mirsaidi A, Tiaden A, Kuhn G, Weber F, Oka C, et al.
PLoS One
. 2017 Jul;
12(7):e0181600.
PMID: 28732055
The role of mammalian high temperature requirement protease A1 (HTRA1) in somatic stem cell differentiation and mineralized matrix formation remains controversial, having been demonstrated to impart either anti- or pro-osteogenic...
28.
Martino M, Maruyama K, Kuhn G, Satoh T, Takeuchi O, Muller R, et al.
Nat Commun
. 2016 Mar;
7:11051.
PMID: 27001940
Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment....
29.
Mirsaidi A, Genelin K, Vetsch J, Stanger S, Theiss F, Lindtner R, et al.
Biomaterials
. 2014 Jun;
35(26):7326-35.
PMID: 24933514
Adipose-derived stromal cells (ASCs) are increasingly being used for orthopedic-based tissue engineering approaches due to their ability to readily undergo osteogenic differentiation. In the present study, we used in vitro...
30.
Martino M, Briquez P, Guc E, Tortelli F, Kilarski W, Metzger S, et al.
Science
. 2014 Feb;
343(6173):885-8.
PMID: 24558160
Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated...