Giridharan Periyasamy
Overview
Explore the profile of Giridharan Periyasamy including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
257
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0
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Recent Articles
1.
Khuntia S, Mukherjee N, Javle V, Tanwar N, Sreekanthreddy P, Varghese L, et al.
JCO Glob Oncol
. 2024 Nov;
10:e2400289.
PMID: 39571115
Purpose: Gene fusions are critical oncogenic mutations that drive cancer development and serve as diagnostic and prognostic biomarkers. Despite the increasing cancer burden in India, large-scale analyses of molecular landscapes,...
2.
Narmada B, Khakpoor A, Shirgaonkar N, Narayanan S, Aw P, Singh M, et al.
J Hepatol
. 2024 Feb;
81(1):42-61.
PMID: 38423478
Background & Aims: Hepatitis B surface antigen (HBsAg) loss or functional cure (FC) is considered the optimal therapeutic outcome for patients with chronic hepatitis B (CHB). However, the immune-pathological biomarkers...
3.
Xiang W, Lam Y, Periyasamy G, Chuah C
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35270002
Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by extensive heterogeneity in genetics, response to therapy and long-term outcomes, making it a prototype example of development for personalized...
4.
Shanmugam R, Ozturk M, Low J, Akincilar S, Chua J, Thangavelu M, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(3).
PMID: 35027447
Cancer-specific promoter mutations reported in 19% of cancers result in enhanced telomerase activity. Understanding the distinctions between transcriptional regulation of wild-type (WT) and mutant (Mut) promoters may open up avenues...
5.
Wong R, Wong M, Kuick C, Saffari S, Wong M, Tan S, et al.
Front Oncol
. 2021 Nov;
11:709525.
PMID: 34722256
Neuroblastoma is the commonest extracranial pediatric malignancy. With few recurrent single nucleotide variations (SNVs), mutation-based precision oncology approaches have limited utility, but its frequent and heterogenous copy number variations (CNVs)...
6.
Low J, Lau D, Zhang X, Kwang X, Rohatgi N, Chan J, et al.
EBioMedicine
. 2021 Apr;
66:103297.
PMID: 33862587
No abstract available.
7.
Low J, Lau D, Zhang X, Kwang X, Rohatgi N, Chan J, et al.
EBioMedicine
. 2021 Feb;
64:103220.
PMID: 33529999
Background: Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs);...
8.
Kong L, Ong R, Tan T, Mohamed Salleh N, Thangavelu M, Chan J, et al.
Nat Commun
. 2020 May;
11(1):2086.
PMID: 32350249
Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms...
9.
Tan J, Li F, Yeo J, Yong K, Bassal M, Ng G, et al.
Gastroenterology
. 2019 Aug;
157(6):1615-1629.e17.
PMID: 31446059
Background & Aims: Some oncogenes encode transcription factors, but few drugs have been successfully developed to block their activity specifically in cancer cells. The transcription factor SALL4 is aberrantly expressed...
10.
Sharma A, Cao E, Kumar V, Zhang X, Leong H, Wong A, et al.
Nat Commun
. 2018 Nov;
9(1):4931.
PMID: 30467425
Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of...