Giovanni Sestini
Overview
Explore the profile of Giovanni Sestini including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
208
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Recent Articles
1.
Santini L, Kowald S, Cerron-Alvan L, Huth M, Fabing A, Sestini G, et al.
Nat Commun
. 2024 Sep;
15(1):7879.
PMID: 39251582
Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN) comprising core and naïve pluripotency-specific transcription factors (TFs). Upon exiting naïve pluripotency, embryonic stem cells (ESCs) transition through a...
2.
Khoei H, Javali A, Kagawa H, Sommer T, Sestini G, David L, et al.
Nat Protoc
. 2023 Feb;
18(5):1584-1620.
PMID: 36792779
Human early development sets the stage for embryonic and adult life but remains difficult to investigate. A solution came from the ability of stem cells to organize into structures resembling...
3.
Kagawa H, Javali A, Khoei H, Sommer T, Sestini G, Novatchkova M, et al.
J Vis Exp
. 2022 Aug;
(186).
PMID: 36036618
A model of the human blastocyst formed from stem cells (blastoid) would support scientific and medical advances. However, its predictive power will depend on its ability to efficiently, timely, and...
4.
Vrij E, Scholte Op Reimer Y, Roa Fuentes L, Misteli Guerreiro I, Holzmann V, Frias Aldeguer J, et al.
Development
. 2022 Aug;
149(20).
PMID: 35993866
Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn). We...
5.
Seong J, Frias-Aldeguer J, Holzmann V, Kagawa H, Sestini G, Khoei H, et al.
Cell Stem Cell
. 2022 Jul;
29(7):1102-1118.e8.
PMID: 35803228
The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an...
6.
Kagawa H, Javali A, Khoei H, Sommer T, Sestini G, Novatchkova M, et al.
Nature
. 2021 Dec;
601(7894):600-605.
PMID: 34856602
One week after fertilization, human embryos implant into the uterus. This event requires the embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo proper....
7.
Sims J, Sestini G, Elgert C, von Haeseler A, Schlogelhofer P
Nat Commun
. 2021 Jan;
12(1):387.
PMID: 33452254
Despite vast differences between organisms, some characteristics of their genomes are conserved, such as the nucleolus organizing region (NOR). The NOR is constituted of multiple, highly repetitive rDNA genes, encoding...