Ginger E Dutschman
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Explore the profile of Ginger E Dutschman including associated specialties, affiliations and a list of published articles.
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36
Citations
312
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Recent Articles
1.
Wang Y, Lee S, Ha Y, Lam W, Chen S, Dutschman G, et al.
Sci Rep
. 2017 Sep;
7(1):10037.
PMID: 28855547
Tylophorine analogs have been shown to exhibit diverse activities against cancer, inflammation, arthritis, and lupus in vivo. In this study, we demonstrated that two tylophorine analogs, DCB-3503 and rac-cryptopleurine, exhibit...
2.
Haraguchi K, Shimada H, Kimura K, Akutsu G, Tanaka H, Abe H, et al.
ACS Med Chem Lett
. 2013 Jun;
2(9):692-697.
PMID: 23795238
The synthesis of 4'-ethynyl-2'-deoxy-4'-thioribonucleosides was carried out utilizing an electrophilic glycosidation in which 4-ethynyl-4-thiofuranoid glycal served as a glycosyl donor. Electrophilic glycosidation between and the silylated nucleobases (-acetylcytosine, -benzoyladenine and...
3.
Piao D, Basavapathruni A, Iyidogan P, Dai G, Hinz W, Ray A, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(5):1511-8.
PMID: 23380374
The onset of resistance to approved anti-AIDS drugs by HIV necessitates the search for novel inhibitors of HIV-1 reverse transcriptase (RT). Developing single molecular agents concurrently occupying the nucleoside and...
4.
Tsou L, Chen C, Dutschman G, Cheng Y, Hamilton A
Bioorg Med Chem Lett
. 2012 Apr;
22(9):3358-61.
PMID: 22487177
We report the mode of action of a proteomimetic compound that binds to the exterior surface of gp120 and blocks HIV-1 entry into cells. Using a one cycle time-of-addition study...
5.
Zhang W, Dutschman G, Li X, Cheng Y
J Chromatogr B Analyt Technol Biomed Life Sci
. 2011 Jun;
879(22):2018-22.
PMID: 21705287
A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the determination of paclitaxel (Taxol) and its two major metabolites in human plasma has been developed. Samples were prepared...
6.
Zhang W, Tan S, Paintsil E, Dutschman G, Gullen E, Chu E, et al.
Biochem Pharmacol
. 2011 May;
82(4):411-7.
PMID: 21620803
Endogenous ribonucleotides and deoxyribonucleotides play a critical role in cell function, and determination of their levels is of fundamental importance in understanding key cellular processes involved in energy metabolism and...
7.
Paintsil E, Dutschman G, Hu R, Grill S, Wang C, Lam W, et al.
Antimicrob Agents Chemother
. 2010 Nov;
55(2):895-903.
PMID: 21078952
Individual variation in response to antiretroviral therapy is well-known, but it is not clear if demographic characteristics such as gender, age, and ethnicity are responsible for the variation. To optimize...
8.
Zhang W, Saif M, Dutschman G, Li X, Lam W, Bussom S, et al.
J Chromatogr A
. 2010 Aug;
1217(37):5785-93.
PMID: 20696432
Traditional Chinese Medicine (TCM) is increasingly being used in combination with Western medicine. In general, TCM is comprised of multiple components in sharp contrast to Western medicine, where a single...
9.
Hines J, Ju R, Dutschman G, Cheng Y, Crews C
J Pharmacol Exp Ther
. 2010 Jun;
334(3):729-38.
PMID: 20571059
The mechanism of action of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol], which potently and selectively inhibits the proliferation of endothelial cells, is incompletely understood. Previous studies have established its binding protein and the...
10.
Tsou L, Dutschman G, Gullen E, Telpoukhovskaia M, Cheng Y, Hamilton A
Bioorg Med Chem Lett
. 2010 Mar;
20(7):2137-9.
PMID: 20202840
A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual...