Gianna Toffolo
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Explore the profile of Gianna Toffolo including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
2069
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Recent Articles
1.
Schiavon M, Cobelli C, Nair K, Klaus K, Toffolo G, Zhang L, et al.
J Cyst Fibros
. 2024 Nov;
24(1):57-65.
PMID: 39516143
Background: Cystic Fibrosis (CF) patients historically suffered from undernutrition, infection and inflammation. Insulin insufficiency-related protein catabolism further compromised health. We aimed to determine whether insulin improves protein catabolism in CF...
2.
Petrucci G, Zaccardi F, Giaretta A, Cavalca V, Capristo E, Cardillo C, et al.
J Thromb Haemost
. 2019 Apr;
17(6):885-895.
PMID: 30933424
Background: The prevalence and degree of obesity is rising worldwide, increases cardiovascular risk, modifies body composition and organ function, and potentially affects the pharmacokinetics and/or pharmacodynamics of drugs. Objectives: To...
3.
Moran A, Toffolo G, Schiavon M, Vella A, Klaus K, Cobelli C, et al.
Am J Physiol Endocrinol Metab
. 2018 Jun;
315(4):E469-E477.
PMID: 29870679
Insulin and nutrients have profound effects on proteome homeostasis. Currently no reliable methods are available to measure postprandial protein turnover. A triple-tracer method was developed using phenylalanine stable isotope tracers...
4.
Rizza R, Toffolo G, Cobelli C
Diabetes
. 2016 May;
65(5):1133-45.
PMID: 27208180
Fasting hyperglycemia occurs when an excessive rate of endogenous glucose production (EGP) is not accompanied by an adequate compensatory increase in the rate of glucose disappearance (Rd). The situation following...
5.
Sambo F, Di Camillo B, Toffolo G, Cobelli C
Bioinformatics
. 2014 Jul;
30(21):3078-85.
PMID: 25064564
Motivation: The increasing interest in rare genetic variants and epistatic genetic effects on complex phenotypic traits is currently pushing genome-wide association study design towards datasets of increasing size, both in...
6.
Cobelli C, Dalla Man C, Pedersen M, Bertoldo A, Toffolo G
IEEE Trans Biomed Eng
. 2014 Apr;
61(5):1577-92.
PMID: 24759285
The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents....
7.
Cobelli C, Dalla Man C, Toffolo G, Basu R, Vella A, Rizza R
Diabetes
. 2014 Mar;
63(4):1203-13.
PMID: 24651807
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal method (i.e., models...
8.
Di Camillo B, Sambo F, Toffolo G, Cobelli C
Bioinformatics
. 2013 Dec;
30(3):384-91.
PMID: 24292361
Motivation: In the past years, both sequencing and microarray have been widely used to search for relations between genetic variations and predisposition to complex pathologies such as diabetes or neurological...
9.
Sambo F, de Oca M, Di Camillo B, Toffolo G, Stutzle T
IEEE/ACM Trans Comput Biol Bioinform
. 2012 Jul;
9(5):1459-71.
PMID: 22837424
Reverse engineering is the problem of inferring the structure of a network of interactions between biological variables from a set of observations. In this paper, we propose an optimization algorithm,...
10.
Eduati F, De Las Rivas J, Di Camillo B, Toffolo G, Saez-Rodriguez J
Bioinformatics
. 2012 Jun;
28(18):2311-7.
PMID: 22734019
Motivation: Recent developments in experimental methods facilitate increasingly larger signal transduction datasets. Two main approaches can be taken to derive a mathematical model from these data: training a network (obtained,...