Gerhard J Schutz
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Explore the profile of Gerhard J Schutz including associated specialties, affiliations and a list of published articles.
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117
Citations
2248
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Recent Articles
1.
Weber F, Axmann M, Sezgin E, Amaro M, Sych T, Hochreiner A, et al.
Membranes (Basel)
. 2024 Dec;
14(12.
PMID: 39728711
The viscoelastic properties of biological membranes are crucial in controlling cellular functions and are determined primarily by the lipids' composition and structure. This work studies these properties by varying the...
2.
Barden M, Elsenbroich P, Haas V, Ertelt M, Pervan P, Velas L, et al.
J Immunother Cancer
. 2024 Dec;
12(12.
PMID: 39622582
Background: The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors indicating the need for adequately tuning...
3.
Advanced Quantification of Receptor-Ligand Interaction Lifetimes via Single-Molecule FRET Microscopy
Schrangl L, Muhlgrabner V, Platzer R, Kellner F, Wieland J, Obst R, et al.
Biomolecules
. 2024 Aug;
14(8).
PMID: 39199389
Receptor-ligand interactions at cell interfaces initiate signaling cascades essential for cellular communication and effector functions. Specifically, T cell receptor (TCR) interactions with pathogen-derived peptides presented by the major histocompatibility complex...
4.
Menon A, Villanueva H, Meraviglia-Crivelli D, van Santen H, Hellmeier J, Zheleva A, et al.
Mol Ther Nucleic Acids
. 2024 May;
35(2):102198.
PMID: 38745854
The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are...
5.
Schrangl L, Gohring J, Kellner F, Huppa J, Schutz G
Methods Mol Biol
. 2024 May;
2800:147-165.
PMID: 38709483
Molecular forces are increasingly recognized as an important parameter to understand cellular signaling processes. In the recent years, evidence accumulated that also T-cells exert tensile forces via their T-cell receptor...
6.
Moura S, Hartl I, Brumovska V, Calabrese P, Yasari A, Striedner Y, et al.
Genome Biol Evol
. 2024 Feb;
16(2).
PMID: 38411226
Delayed fatherhood results in a higher risk of inheriting a new germline mutation that might result in a congenital disorder in the offspring. In particular, some FGFR3 mutations increase in...
7.
Platzer R, Hellmeier J, Gohring J, Perez I, Schatzlmaier P, Bodner C, et al.
EMBO Rep
. 2023 Sep;
24(11):e57842.
PMID: 37768718
Molecular crowding of agonist peptide/MHC class II complexes (pMHCIIs) with structurally similar, yet per se non-stimulatory endogenous pMHCIIs is postulated to sensitize T-cells for the recognition of single antigens on...
8.
Schutz G, Pabst G
Bioessays
. 2023 Sep;
45(12):e2300116.
PMID: 37712937
One persistent puzzle in the life sciences is the asymmetric lipid composition of the cellular plasma membrane: while the exoplasmic leaflet is enriched in lipids carrying predominantly saturated fatty acids,...
9.
Bodner C, Kiesenhofer D, Schutz G, Brameshuber M
Biophys J
. 2023 Apr;
122(11):2367-2380.
PMID: 37088991
The interplay and communication between cells build the foundation of life. Many signaling processes at the cell surface and inside the cell, as well as the cellular function itself, depend...
10.
Barden M, Holzinger A, Velas L, Mezosi-Csaplar M, Szoor A, Vereb G, et al.
Front Immunol
. 2023 Feb;
14:1110482.
PMID: 36817444
In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated...