Gerd Mittelstadt
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Explore the profile of Gerd Mittelstadt including associated specialties, affiliations and a list of published articles.
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12
Citations
168
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Recent Articles
1.
Montgomerie I, Bird T, Palmer O, Mason N, Pankhurst T, Lawley B, et al.
iScience
. 2023 Feb;
26(4):106256.
PMID: 36845030
Emerging SARS-CoV-2 variants pose a threat to human health worldwide. SARS-CoV-2 receptor binding domain (RBD)-based vaccines are suitable candidates for booster vaccines, eliciting a focused antibody response enriched for virus...
2.
Scully T, Jiao W, Mittelstadt G, Parker E
Philos Trans R Soc Lond B Biol Sci
. 2023 Jan;
378(1871):20220039.
PMID: 36633281
Anthranilate phosphoribosyltransferase catalyses the second reaction in the biosynthesis of tryptophan from chorismate in microorganisms and plants. The enzyme is homodimeric with the active site located in the hinge region...
3.
Jiao W, Mittelstadt G, Parker E
Biochemistry
. 2022 Aug;
61(17):1883-1893.
PMID: 35969806
Enzyme-catalyzed hydrolysis is a fundamental chemical transformation involved in many essential metabolic processes. The enzyme 5'-methylthioadenosine/-adenosylhomocysteine nucleosidase (MTAN) catalyzes the hydrolysis of adenosine-containing metabolites in cysteine and methionine metabolism. Although...
4.
Radon C, Mittelstadt G, Duffus B, Burger J, Hartmann T, Mielke T, et al.
Nat Commun
. 2020 Apr;
11(1):1912.
PMID: 32313256
Metal-containing formate dehydrogenases (FDH) catalyse the reversible oxidation of formate to carbon dioxide at their molybdenum or tungsten active site. They display a diverse subunit and cofactor composition, but structural...
5.
Hinge Twists and Population Shifts Deliver Regulated Catalysis for ATP-PRT in Histidine Biosynthesis
Jiao W, Mittelstadt G, Moggre G, Parker E
Biophys J
. 2019 May;
116(10):1887-1897.
PMID: 31053263
Allosteric regulation plays an important role in the control of metabolic flux in biosynthetic pathways. In microorganisms, many enzymes in these pathways adopt different strategies of allostery to allow the...
6.
Mittelstadt G, Jiao W, Livingstone E, Moggre G, Nazmi A, Parker E
Biochem J
. 2017 Dec;
475(1):247-260.
PMID: 29208762
Adenosine triphosphate (ATP) phosphoribosyltransferase (ATP-PRT) catalyses the first committed step of histidine biosynthesis in plants and microorganisms. Two forms of ATP-PRT have been reported, which differ in their molecular architecture...
7.
Livingstone E, Mittelstadt G, Given F, Parker E
FEBS Lett
. 2016 Jul;
590(16):2603-10.
PMID: 27393206
ATP-phosphoribosyltransferase (ATP-PRT) catalyses the first step of histidine biosynthesis. Two different forms of ATP-PRT have been described; the homo-hexameric long form, and the hetero-octameric short form. Lactococcus lactis possesses the...
8.
Mittelstadt G, Moggre G, Panjikar S, Nazmi A, Parker E
Protein Sci
. 2016 May;
25(8):1492-506.
PMID: 27191057
Adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyzes the first committed step of the histidine biosynthesis in plants and microorganisms. Here, we present the functional and structural characterization of the ATP-PRT from the...
9.
Lang E, Cross P, Mittelstadt G, Jameson G, Parker E
Curr Opin Struct Biol
. 2014 Dec;
29:102-11.
PMID: 25543886
Allosteric regulation of enzyme activity plays important metabolic roles. Here we review the allostery of enzymes of amino-acid metabolism conferred by a discrete domain known as the ACT domain. This...
10.
Mittelstadt G, Negron L, Schofield L, Marsh K, Parker E
Arch Biochem Biophys
. 2013 Aug;
537(2):185-91.
PMID: 23916589
One of the novel aspects of kiwifruit is the presence of a high level of quinic acid which contributes to the flavour of the fruit. Quinic acid metabolism intersects with...