Gerard Manning
Overview
Explore the profile of Gerard Manning including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
65
Citations
8461
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Horne C, Dite T, Young S, Mather L, Dagley L, Johnson J, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2420961122.
PMID: 39964718
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1...
2.
Jones A, Kornev A, Weng J, Manning G, Taylor S, Newton A
Biochem J
. 2023 Aug;
480(16):1299-1316.
PMID: 37551632
Conventional protein kinase C (cPKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition...
3.
Jones A, Kornev A, Weng J, Manning G, Taylor S, Newton A
bioRxiv
. 2023 Mar;
PMID: 36993163
Conventional protein kinase C (PKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition...
4.
Rinaldi J, Sokol E, Hartmaier R, Trabucco S, Frampton G, Goldberg M, et al.
PLoS One
. 2020 May;
15(5):e0231999.
PMID: 32374727
Background: Metastatic breast cancer is the leading cause of cancer death in women, but the genomics of metastasis in breast cancer are poorly studied. Methods: We explored a set of...
5.
Petrie E, Sandow J, Lehmann W, Liang L, Coursier D, Young S, et al.
Cell Rep
. 2019 Sep;
28(13):3309-3319.e5.
PMID: 31553902
Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the kinase...
6.
Daemen A, Manning G
Breast Cancer Res
. 2018 Feb;
20(1):8.
PMID: 29382369
Background: Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of...
7.
Chen M, Dixon J, Manning G
Sci Signal
. 2017 Apr;
10(474).
PMID: 28400531
Protein phosphatases are the essential opposite to protein kinases; together, these enzymes regulate all protein phosphorylation and most cellular processes. To better understand the global roles of protein phosphorylation, we...
8.
Foster S, Whalen D, Ozen A, Wongchenko M, Yin J, Yen I, et al.
Cancer Cell
. 2016 Mar;
29(4):477-493.
PMID: 26996308
Activating mutations in protein kinases drive many cancers. While how recurring point mutations affect kinase activity has been described, the effect of in-frame deletions is not well understood. We show...
9.
Newton K, Manning G
Annu Rev Biochem
. 2016 Feb;
85:743-63.
PMID: 26865533
Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing intracellular components that can trigger an innate immune response. Toll-like receptor 3 and 4 agonists, tumor...
10.
Babbitt P, Bagos P, Bairoch A, Bateman A, Chatonnet A, Chen M, et al.
Database (Oxford)
. 2015 Aug;
2015:bav063.
PMID: 26284514
During 11-12 August 2014, a Protein Bioinformatics and Community Resources Retreat was held at the Wellcome Trust Genome Campus in Hinxton, UK. This meeting brought together the principal investigators of...