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Gerard L Heck

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Articles 18
Citations 346
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Recent Articles
1.
Qian J, Mummalaneni S, Phan T, Heck G, DeSimone J, West D, et al.
PLoS One . 2017 Feb; 12(2):e0171335. PMID: 28192441
During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF)...
2.
DeSimone J, Phan T, Mummalaneni S, Rhyu M, Heck G, Lyall V
Chem Senses . 2015 May; 40(6):401-12. PMID: 25953775
Modulatory effects of pHi and [Ca(2+)]i on taste receptor cell (TRC) epithelial sodium channel (ENaC) were investigated by monitoring chorda tympani (CT) responses to NaCl and KCl at various lingual...
3.
Mummalaneni S, Qian J, Phan T, Rhyu M, Heck G, DeSimone J, et al.
PLoS One . 2014 May; 9(5):e98049. PMID: 24839965
The effects of small molecule ENaC activators N,N,N-trimethyl-2-((4-methyl-2-((4-methyl-1H-indol-3-yl)thio)pentanoyl)oxy)ethanaminium iodide (Compound 1) and N-(2-hydroxyethyl)-4-methyl-2-((4-methyl-1H-indol-3-yl)thio)pentanamide (Compound 2), were tested on the benzamil (Bz)-sensitive NaCl chorda tympani (CT) taste nerve response under open-circuit...
4.
DeSimone J, Ren Z, Phan T, Heck G, Mummalaneni S, Lyall V
J Neurophysiol . 2012 Sep; 108(12):3206-20. PMID: 22956787
The relationship between taste receptor cell (TRC) Ca(2+) concentration ([Ca(2+)](i)) and rat chorda tympani (CT) nerve responses to salty [NaCl and NaCl+benzamil (Bz)] and sour (HCl, CO(2), and acetic acid)...
5.
DeSimone J, Phan T, Heck G, Ren Z, Coleman J, Mummalaneni S, et al.
Chem Senses . 2011 Feb; 36(4):389-403. PMID: 21339339
To investigate if chorda tympani (CT) taste nerve responses to strong (HCl) and weak (CO(2) and acetic acid) acidic stimuli are dependent upon NADPH oxidase-linked and cAMP-sensitive proton conductances in...
6.
Feldman G, Heck G, Smith N
Chem Senses . 2009 Mar; 34(5):373-82. PMID: 19282337
We have demonstrated in humans that Na(+) evokes changes in the lingual surface potential (LSP) using a custom chamber. To assess whether a relationship exists between the Na(+)-evoked changes in...
7.
Lyall V, Phan T, Mummalaneni S, Mansouri M, Heck G, Kobal G, et al.
J Neurophysiol . 2007 Jul; 98(3):1662-74. PMID: 17615133
The effect of nicotine on the benzamil (Bz)-insensitive (transient receptor potential vanilloid-1 variant cation channel, TRPV1t) and the Bz-sensitive (epithelial Na(+) channel, ENaC) salt taste receptors and sour taste was...
8.
Treesukosol Y, Lyall V, Heck G, DeSimone J, Spector A
Am J Physiol Regul Integr Comp Physiol . 2007 Jan; 292(5):R1799-809. PMID: 17234959
Current evidence suggests salt taste transduction involves at least two mechanisms, one that is amiloride sensitive and appears to use apically located epithelial sodium channels relatively selective for Na(+) and...
9.
Lyall V, Pasley H, Phan T, Mummalaneni S, Heck G, Vinnikova A, et al.
J Gen Physiol . 2005 Dec; 127(1):15-34. PMID: 16380442
The relationship between cell volume and the neural response to acidic stimuli was investigated by simultaneous measurements of intracellular pH (pHi) and cell volume in polarized fungiform taste receptor cells...
10.
Lyall V, Heck G, Phan T, Mummalaneni S, Malik S, Vinnikova A, et al.
J Gen Physiol . 2005 Jun; 125(6):587-600. PMID: 15928404
The effect of ethanol on the amiloride- and benzamil (Bz)-insensitive salt taste receptor was investigated by direct measurement of intracellular Na(+) activity ([Na(+)](i)) using fluorescence imaging in polarized fungiform taste...