Gerard D Schellenberg
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Explore the profile of Gerard D Schellenberg including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Abu-Amara H, Zhao W, Li Z, Leung Y, Schellenberg G, Wang L, et al.
medRxiv
. 2024 Jan;
PMID: 38293024
The prevalence of dementia among South Asians across India is approximately 7.4% in those 60 years and older, yet little is known about genetic risk factors for dementia in this...
22.
Leung Y, Naj A, Chou Y, Valladares O, Schmidt M, Hamilton-Nelson K, et al.
Nat Commun
. 2024 Jan;
15(1):684.
PMID: 38263370
The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across...
23.
Wang H, Chang T, Dombroski B, Cheng P, Patil V, Valiente-Banuet L, et al.
medRxiv
. 2024 Jan;
PMID: 38234807
Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP were...
24.
Ho P, Yu W, Tee B, Lee W, Li C, Gu Y, et al.
Alzheimers Dement
. 2024 Jan;
20(3):2058-2071.
PMID: 38215053
Introduction: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians...
25.
Vance J, Farrer L, Huang Y, Cruchaga C, Hyman B, Pericak-Vance M, et al.
Ann Neurol
. 2024 Jan;
95(4):625-634.
PMID: 38180638
Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest genetic risk factor for...
26.
Guo M, Lee W, Vardarajan B, Schellenberg G, Phillips-Cremins J
medRxiv
. 2023 Nov;
PMID: 38014121
Studies of the genetics of Alzheimer's disease (AD) have largely focused on single nucleotide variants and short insertions/deletions. However, most of the disease heritability has yet to be uncovered, suggesting...
27.
Archer D, Eissman J, Mukherjee S, Lee M, Choi S, Scollard P, et al.
Alzheimers Dement
. 2023 Nov;
20(2):1268-1283.
PMID: 37985223
Introduction: Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. Methods: We conducted a cross-ancestry...
28.
Eissman J, Archer D, Mukherjee S, Lee M, Choi S, Scollard P, et al.
Alzheimers Dement
. 2023 Nov;
20(2):1250-1267.
PMID: 37984853
Background: Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain...
29.
Wang H, Dombroski B, Cheng P, Tucci A, Si Y, Farrell J, et al.
medRxiv
. 2023 Sep;
PMID: 37745545
Structural variations (SVs) are important contributors to the genetics of numerous human diseases. However, their role in Alzheimer's disease (AD) remains largely unstudied due to challenges in accurately detecting SVs....
30.
Ray N, Kunkle B, Hamilton-Nelson K, Kurup J, Rajabli F, Cosacak M, et al.
medRxiv
. 2023 Sep;
PMID: 37693582
Introduction: Despite a two-fold increased risk, individuals of African ancestry have been significantly underrepresented in Alzheimer's Disease (AD) genomics efforts. Methods: GWAS of 2,903 AD cases and 6,265 cognitive controls...