Geraldine M Mitchell
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Explore the profile of Geraldine M Mitchell including associated specialties, affiliations and a list of published articles.
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35
Citations
451
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Recent Articles
1.
NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells
Kong A, Idris Z, Urrutia-Cabrera D, Lees J, Phang R, Mitchell G, et al.
Biochem Biophys Rep
. 2024 Dec;
40:101876.
PMID: 39634339
Incorporation of blood capillaries in engineered tissues and their functional connection to host blood vessels is essential for success in engineering vascularized tissues, a process which involves spatial patterning of...
2.
Alkazemi H, Mitchell G, Lokmic-Tomkins Z, Heath D, OConnor A
Acta Biomater
. 2024 Oct;
189:168-178.
PMID: 39368723
A major roadblock in implementing engineered tissues clinically lies in their limited vascularization. After implantation, such tissues do not integrate with the host's circulation as quickly as needed, commonly resulting...
3.
Yap K, Schroder J, Gerrand Y, Dobric A, Kong A, Fox A, et al.
JHEP Rep
. 2024 Apr;
6(5):101023.
PMID: 38681862
Background & Aims: Liver sinusoidal endothelial cells (LSECs) are important in liver development, regeneration, and pathophysiology, but the differentiation process underlying their tissue-specific phenotype is poorly understood and difficult to...
4.
Davies E, Gurung R, Le K, Roan K, Harvey R, Mitchell G, et al.
Sci Adv
. 2023 Mar;
9(13):eadd6911.
PMID: 37000875
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P to PI(3,4,5)P, activating AKT;...
5.
Kong A, Lim S, Palmer J, Rixon A, Gerrand Y, Yap K, et al.
J Tissue Eng
. 2023 Jan;
13:20417314221140979.
PMID: 36600999
Due to a relative paucity of studies on human lymphatic assembly in vitro and subsequent in vivo transplantation, capillary formation and survival of primary human lymphatic (hLEC) and blood endothelial...
6.
Yap K, Gerrand Y, Dingle A, Yeoh G, Morrison W, Mitchell G
Biomaterials
. 2020 May;
251:120091.
PMID: 32408048
The structural and physiological complexity of currently available liver organoids is limited, thereby reducing their relevance for drug studies, disease modelling, and regenerative therapy. In this study we combined mouse...
7.
Rnjak-Kovacina J, Gerrand Y, Wray L, Tan B, Joukhdar H, Kaplan D, et al.
Adv Healthc Mater
. 2019 Nov;
8(24):e1901106.
PMID: 31714024
Poor vascularization remains a key limiting factor in translating advances in tissue engineering to clinical applications. Vascular pedicles (large arteries and veins) isolated in plastic chambers are known to sprout...
8.
Kong A, Yap K, Lim S, Marre D, Pebay A, Gerrand Y, et al.
Acta Biomater
. 2019 Jun;
94:281-294.
PMID: 31152943
Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a tissue flap is assembled using the mammalian body as...
9.
Wang J, Chen J, Kuo S, Mitchell G, Lim S, Liu G
Methods Mol Biol
. 2019 Jun;
1993:217-226.
PMID: 31148090
The success of tissue engineering hinges on the rapid and sufficient vascularization of the neotissue. For efficient vascular network formation within three-dimensional (3D) constructs, biomaterial scaffolds that can support survival...
10.
Williams M, Joglekar M, Satoor S, Wong W, Keramidaris E, Rixon A, et al.
Cell Transplant
. 2018 Nov;
28(1):89-104.
PMID: 30376726
Type 1 diabetes (T1D) is characterized by the loss of insulin-producing β-cells in the pancreas. T1D can be treated using cadaveric islet transplantation, but this therapy is severely limited by...