Georges St Laurent
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Explore the profile of Georges St Laurent including associated specialties, affiliations and a list of published articles.
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23
Citations
1361
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Recent Articles
1.
Diao Y, Rahman M, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, et al.
Mol Oncol
. 2018 Aug;
12(10):1718-1734.
PMID: 30098229
Hedgehog (HH) signaling is involved in many physiological processes, and pathway deregulation can result in a wide range of malignancies. Glioma-associated oncogene 1 (GLI1) is a transcription factor and a...
2.
Toma I, St Laurent G, McCaffrey T
Per Med
. 2018 May;
8(4):483-491.
PMID: 29783338
The sequencing of the human genome, combined with brilliant technical advances in microarrays and computing, opened the genomic era of personalized medicine. The next generation of genomics is now being...
3.
Savva Y, Rezaei A, St Laurent G, Reenan R
Front Genet
. 2016 Jul;
7:100.
PMID: 27458478
Transcription of genetic information from archival DNA into RNA molecule working copies is vital for proper cellular function and is highly accurate. In turn, RNAs serve structural, enzymatic, and regulatory...
4.
St Laurent G, Vyatkin Y, Antonets D, Ri M, Qi Y, Saik O, et al.
Nucleic Acids Res
. 2016 Mar;
44(7):3233-52.
PMID: 27001520
Functionality of the non-coding transcripts encoded by the human genome is the coveted goal of the modern genomics research. While commonly relied on the classical methods of forward genetics, integration...
5.
Savva Y, St Laurent G, Reenan R
Methods Mol Biol
. 2015 Oct;
1358:255-68.
PMID: 26463388
Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing system is particularly active...
6.
Pastori C, Kapranov P, Penas C, Peschansky V, Volmar C, Sarkaria J, et al.
Proc Natl Acad Sci U S A
. 2015 Jun;
112(27):8326-31.
PMID: 26111795
Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes...
7.
St Laurent G, Wahlestedt C, Kapranov P
Trends Genet
. 2015 Apr;
31(5):239-51.
PMID: 25869999
Advances in the depth and quality of transcriptome sequencing have revealed many new classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to accommodate these new findings, even though...
8.
Lazorthes S, Vallot C, Briois S, Aguirrebengoa M, Thuret J, St Laurent G, et al.
Nat Commun
. 2015 Apr;
6:6918.
PMID: 25850412
No abstract available.
9.
Lazorthes S, Vallot C, Briois S, Aguirrebengoa M, Thuret J, St Laurent G, et al.
Nat Commun
. 2015 Jan;
6:5971.
PMID: 25601475
Non-coding RNAs (ncRNAs) play major roles in proper chromatin organization and function. Senescence, a strong anti-proliferative process and a major anticancer barrier, is associated with dramatic chromatin reorganization in heterochromatin...
10.
St Laurent G, Vyatkin Y, Kapranov P
BMC Med
. 2014 Jun;
12:97.
PMID: 24924000
In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted...