Georges de Sousa
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Explore the profile of Georges de Sousa including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
303
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Recent Articles
1.
Amezian D, Fricaux T, de Sousa G, Maiwald F, Huditz H, Nauen R, et al.
Pestic Biochem Physiol
. 2023 Sep;
195:105563.
PMID: 37666619
Spodoptera frugiperda (fall armyworm, FAW) is an invasive polyphagous lepidopteran pest that has developed sophisticated resistance mechanisms involving detoxification enzymes to eliminate toxic compounds it encounters in its diet including...
2.
Alarcan J, de Sousa G, Katsanou E, Spyropoulou A, Batakis P, Machera K, et al.
Arch Toxicol
. 2021 Nov;
96(1):211-229.
PMID: 34778935
Within the EuroMix project, we have previously developed an adverse outcome pathway (AOP)-based in vitro assay toolbox to investigate the combined effects of liver steatosis-inducing compounds in human HepaRG hepatocarcinoma...
3.
Ruttanaphan T, de Sousa G, Pengsook A, Pluempanupat W, Huditz H, Bullangpoti V, et al.
Insects
. 2020 Oct;
11(10).
PMID: 33050622
, a highly polyphagous insect pest from America, has recently invaded and widely spread throughout Africa and Asia. Effective and environmentally safe tools are needed for successful pest management of...
4.
Tebby C, Voet H, de Sousa G, Rorije E, Kumar V, de Boer W, et al.
Food Chem Toxicol
. 2020 May;
142:111440.
PMID: 32473292
Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic...
5.
Lichtenstein D, Luckert C, Alarcan J, de Sousa G, Gioutlakis M, Katsanou E, et al.
Food Chem Toxicol
. 2020 Mar;
139:111283.
PMID: 32201337
Exposure to complex chemical mixtures requires a tiered strategy for efficient mixture risk assessment. As a part of the EuroMix project we developed an adverse outcome pathway (AOP)-based assay toolbox...
6.
Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole
Luckert C, Braeuning A, de Sousa G, Durinck S, Katsanou E, Konstantinidou P, et al.
Chem Res Toxicol
. 2018 Jul;
31(8):784-798.
PMID: 29995386
Adverse outcome pathways (AOPs) describe causal relationships between molecular perturbation and adverse cellular effects and are being increasingly adopted for linking in vitro mechanistic toxicology to in vivo data from...
7.
Kadar A, de Sousa G, Peyre L, Wortham H, Doumenq P, Rahmani R
Chemosphere
. 2017 May;
181:666-674.
PMID: 28476006
General population exposure to pesticides mainly occurs via food and water consumption. However, their risk assessment for regulatory purposes does not currently consider the actual co-exposure to multiple substances. To...
8.
Braud L, Battault S, Meyer G, Nascimento A, Gaillard S, de Sousa G, et al.
J Nutr Biochem
. 2016 Nov;
40:95-104.
PMID: 27866076
Oxidative stress could trigger lipid accumulation in liver and thus hepatic steatosis. Tea is able to prevent liver disorders, but a direct link between antioxidant capacities and prevention of steatosis...
9.
de Sousa G, Teng S, Salle-Siri R, Pery A, Rahmani R
Food Chem Toxicol
. 2016 Feb;
90:55-63.
PMID: 26829614
Benzophenone-2 (BP2) is widely used as a UV screen in both industrial products and cosmetic formulations, where it is frequently found associated with fragrance compounds, such as isoeugenol and coumarin....
10.
Braud L, Peyre L, de Sousa G, Armand M, Rahmani R, Maixent J
Molecules
. 2015 Aug;
20(8):14985-5002.
PMID: 26287152
Tea is an interesting source of antioxidants capable of counteracting the oxidative stress implicated in liver diseases. We investigated the impact of antioxidant molecules provided by a mixture of teas'...