George Tellides
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Explore the profile of George Tellides including associated specialties, affiliations and a list of published articles.
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169
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5439
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Recent Articles
11.
Ren P, Jiang B, Hassab A, Li G, Li W, Assi R, et al.
bioRxiv
. 2024 May;
PMID: 38746256
Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults. We analyzed single-cell transcriptomes of SMCs...
12.
Jiang B, Ren P, He C, Wang M, Murtada S, Chen Y, et al.
bioRxiv
. 2024 May;
PMID: 38712205
Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection in patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, the common...
13.
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R
JCI Insight
. 2024 Apr;
9(9).
PMID: 38592807
BACKGROUNDDisease of the aorta varies from atherosclerosis to aneurysms, with complications including rupture, dissection, and poorly characterized limited tears. We studied limited tears without any mural hematoma, termed intimomedial tears,...
14.
Rego B, Murtada S, Li G, Tellides G, Humphrey J
Biomech Model Mechanobiol
. 2023 Dec;
23(2):687-701.
PMID: 38151614
Despite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically...
15.
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, et al.
Nat Commun
. 2023 Dec;
14(1):8404.
PMID: 38110370
No abstract available.
16.
Wang S, Song G, Barkestani M, Tobiasova Z, Wang Q, Jiang Q, et al.
Front Immunol
. 2023 Nov;
14:1248027.
PMID: 37915586
Introduction: Ischemia reperfusion injury (IRI) confers worsened outcomes and is an increasing clinical problem in solid organ transplantation. Previously, we identified a "Ptch" T-cell subset that selectively received costimulatory signals...
17.
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, et al.
Science
. 2023 Jul;
381(6654):231-239.
PMID: 37440641
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria documented...
18.
Zhu X, Wang Y, Soaita I, Lee H, Bae H, Boutagy N, et al.
Cell Metab
. 2023 Jun;
35(7):1163-1178.e10.
PMID: 37327791
Endothelial-to-mesenchymal transition (EndMT), a process initiated by activation of endothelial TGF-β signaling, underlies numerous chronic vascular diseases and fibrotic states. Once induced, EndMT leads to a further increase in TGF-β...
19.
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, et al.
Nat Commun
. 2023 Jun;
14(1):3336.
PMID: 37286577
No abstract available.
20.
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, et al.
Nat Commun
. 2023 May;
14(1):3002.
PMID: 37225719
Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation. Informed by proteomics analyses of FACS-sorted inflammasomes, we identify a protein...