George Sigounas
Overview
Explore the profile of George Sigounas including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1151
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0
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Recent Articles
11.
Sigounas G, Hairr J, Cooke C, Owen J, Asch A, Weidner D, et al.
Free Radic Biol Med
. 2010 Mar;
49(1):77-87.
PMID: 20347033
Complex DNA damage may manifest in double-strand breaks (DSBs) and non-DSB, bistranded, oxidatively induced clustered DNA lesions (OCDLs). Although the carcinogen benzo[alpha]pyrene (B[alpha]P) has been shown to induce chromosomal aberrations...
12.
Sigounas G, Salleng K, Mehlhop P, Sigounas D
Int J Cancer
. 2008 Mar;
122(12):2851-7.
PMID: 18350568
Organ toxicity induced by chemotherapeutic drugs is a serious obstacle in the effective treatment of patients suffering from cancer and autoimmune disease. A strong association exists between pulmonary toxicity, particularly...
13.
Francisco D, Peddi P, Hair J, Flood B, Cecil A, Kalogerinis P, et al.
Free Radic Biol Med
. 2007 Nov;
44(4):558-69.
PMID: 18005669
Oxidatively induced stress and DNA damage have been associated with various human pathophysiological conditions, including cancer and aging. Complex DNA damage such as double-strand breaks (DSBs) and non-DSB bistranded oxidatively...
14.
Gollapalle E, Wang R, Adetolu R, Tsao D, Francisco D, Sigounas G, et al.
Radiat Res
. 2007 Mar;
167(2):207-16.
PMID: 17390728
Bistranded oxidative clustered DNA lesions are closely spaced lesions (1-10 bp) that challenge the DNA repair mechanisms and are associated with genomic instability. The endogenous levels of oxidative clustered DNA...
15.
Blackwell K, Gascon P, Sigounas G, Jolliffe L
Oncologist
. 2004 Dec;
9 Suppl 5:41-7.
PMID: 15591421
Within the past decade, clinical trials have shown that the presence of anemia can diminish the physical status, functional abilities, and overall quality of life (QOL) of cancer patients and...
16.
Sallah S, Husain A, Sigounas V, Wan J, Turturro F, Sigounas G, et al.
Clin Cancer Res
. 2004 Nov;
10(21):7238-43.
PMID: 15534097
Purpose: To correlate the concentration of plasma coagulation markers at baseline and during follow-up in patients with solid tumors and venous thromboembolic disease with the risk of recurrence and death....
17.
Sigounas G, Sallah S, Sigounas V
Cancer Lett
. 2004 Sep;
214(2):171-9.
PMID: 15363543
In this study, we assessed the ability of erythropoietin (EPO) to synergize with various chemotherapeutic agents and suppress the growth and metastasis of solid tumors. Animals were inoculated with Lewis...