George S Robertson
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Explore the profile of George S Robertson including associated specialties, affiliations and a list of published articles.
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56
Citations
863
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Recent Articles
1.
Kasheke G, Hendy B, Dorighello G, Uccelli N, Gothie J, Novorolsky R, et al.
Acta Neuropathol Commun
. 2024 Dec;
12(1):197.
PMID: 39707547
Evidence that myelin repair is crucial for functional recovery in multiple sclerosis (MS) led to the identification of bexarotene (BXT). This clinically promising remyelinating agent activates multiple nuclear hormone receptor...
2.
Bigham N, Novorolsky R, Davis K, Zou H, MacMillan S, Stevenson M, et al.
Inorg Chem Front
. 2024 Aug;
11(16):5064-5079.
PMID: 39113903
The transmembrane protein known as the mitochondrial calcium uniporter (MCU) mediates the influx of calcium ions (Ca) into the mitochondrial matrix. An overload of mitochondrial Ca ( Ca) is directly...
3.
Xu P, Swain S, Novorolsky R, Garcia E, Huang Z, Snutch T, et al.
Br J Pharmacol
. 2024 May;
181(18):3503-3526.
PMID: 38779706
Background And Purpose: Excitotoxicity due to mitochondrial calcium (Ca) overloading can trigger neuronal cell death in a variety of pathologies. Inhibiting the mitochondrial calcium uniporter (MCU) has been proposed as...
4.
Novorolsky R, Kasheke G, Hakim A, Foldvari M, Dorighello G, Sekler I, et al.
Front Cell Neurosci
. 2023 Jul;
17:1226630.
PMID: 37484823
The neurovascular unit (NVU) is composed of vascular cells, glia, and neurons that form the basic component of the blood brain barrier. This intricate structure rapidly adjusts cerebral blood flow...
5.
Woods J, Novorolsky R, Bigham N, Robertson G, Wilson J
RSC Chem Biol
. 2023 Jan;
4(1):84-93.
PMID: 36685255
Dysregulation of mitochondrial calcium uptake mediated by the mitochondrial calcium uniporter (MCU) is implicated in several pathophysiological conditions. Dinuclear ruthenium complexes are effective inhibitors of the MCU and have been...
6.
Kasheke G, Holman S, Robertson G
J Neuroimmunol
. 2022 Jul;
370:577926.
PMID: 35863299
Fingolimod, used to treat relapsing-remitting multiple sclerosis (RRMS), reduces motor deficits in mice with established experimental autoimmune encephalomyelitis (EAE). To better characterize the therapeutic effects of fingolimod, kinematic gait analysis...
7.
Tavasoli M, Lahire S, Sokolenko S, Novorolsky R, Reid S, Lefsay A, et al.
Nat Commun
. 2022 Mar;
13(1):1559.
PMID: 35322809
CHKB encodes one of two mammalian choline kinase enzymes that catalyze the first step in the synthesis of the membrane phospholipid phosphatidylcholine. In humans and mice, inactivation of the CHKB...
8.
Deurveilher S, Ko K, Saumure B, Robertson G, Rusak B, Semba K
Sleep
. 2020 Nov;
44(4).
PMID: 33186470
Sleep and circadian rhythm disruptions commonly occur in individuals with schizophrenia. Stable tubule only polypeptide (STOP) knockout (KO) mice show behavioral impairments resembling symptoms of schizophrenia. We previously reported that...
9.
Holman S, Lobo A, Novorolsky R, Nichols M, Fiander M, Konda P, et al.
Exp Neurol
. 2020 Aug;
333:113430.
PMID: 32745471
High-capacity mitochondrial calcium (Ca) uptake by the mitochondrial Ca uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, buffering...
10.
Hall S, Deurveilher S, Robertson G, Semba K
Sleep
. 2020 Jun;
43(11).
PMID: 32474610
Chronic sleep restriction (CSR) negatively impacts brain functions. Whether microglia, the brain's resident immune cells, play any role is unknown. We studied microglia responses to CSR using a rat model...