George M C Janssen
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Explore the profile of George M C Janssen including associated specialties, affiliations and a list of published articles.
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54
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1509
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Recent Articles
11.
van Leeuwen T, Araman C, Pieper Pournara L, Kampstra A, Bakkum T, Marqvorsen M, et al.
RSC Chem Biol
. 2021 Jul;
2(3):855-862.
PMID: 34212151
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof...
12.
Kollenstart L, van der Horst S, Vreeken K, Janssen G, Martino F, Vlaming H, et al.
Sci Rep
. 2021 Jun;
11(1):12795.
PMID: 34140538
The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations, such as crotonylation, succinylation and butyrylation, yet their regulation is still...
13.
Pirro M, Mohammed Y, de Ru A, Janssen G, Tjokrodirijo R, Madunic K, et al.
Int J Mol Sci
. 2021 Jun;
22(10).
PMID: 34065225
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra...
14.
Uribe M, Martin-Nieto J, Quereda C, Rubio-Fernandez M, Cruces J, Janssen G, et al.
J Proteome Res
. 2021 May;
20(6):3268-3277.
PMID: 34027671
Mutations in the 1 gene, encoding a protein -mannosyltransferase essential for α-dystroglycan (α-DG) glycosylation, are frequently observed in a group of rare congenital muscular dystrophies, collectively known as dystroglycanopathies. However,...
15.
Venema W, Hiddingh S, de Boer J, Claas F, Mulder A, den Hollander A, et al.
Front Immunol
. 2021 Mar;
12:634441.
PMID: 33717175
Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked with BU, an aminopeptidase which trims peptides before their presentation by HLA...
16.
Cabukusta B, Berlin I, van Elsland D, Forkink I, Spits M, de Jong A, et al.
Cell Rep
. 2020 Dec;
33(10):108475.
PMID: 33296653
Membrane contact sites (MCS) are intracellular regions where two organelles come closer to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS are attributed to the ER-localized...
17.
de Waard A, Verkerk T, Jongsma M, Hoefakker K, Sethumadhavan S, Gerke C, et al.
Eur J Immunol
. 2020 Dec;
51(3):734-737.
PMID: 33275281
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of...
18.
Hos B, Camps M, van den Bulk J, Tondini E, van den Ende T, Ruano D, et al.
Oncoimmunology
. 2020 Sep;
9(1):1673125.
PMID: 32923109
The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endogenous...
19.
Verheul M, Janssen G, de Ru A, Stoeken-Rijsbergen G, Levarht E, Kwekkeboom J, et al.
Clin Exp Rheumatol
. 2020 Sep;
39(3):570-577.
PMID: 32896247
Objectives: Antibodies targeting post-translationally modified proteins, such as anti-carbamylated protein antibodies (anti-CarP antibodies) are present in the sera of rheumatoid arthritis (RA) patients. These autoantibodies associate with increased risk of...
20.
Kooij R, Liu S, Sapmaz A, Xin B, Janssen G, Van Veelen P, et al.
J Am Chem Soc
. 2020 Sep;
142(39):16825-16841.
PMID: 32886496
Many reagents have emerged to study the function of specific enzymes On the other hand, target specific reagents are scarce or need improvement, allowing investigations of the function of individual...