George L Kellett
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Explore the profile of George L Kellett including associated specialties, affiliations and a list of published articles.
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16
Citations
742
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Recent Articles
1.
2.
Kellett G
Nutr Rev
. 2011 Jul;
69(7):347-70.
PMID: 21729089
Transcellular models of dietary Ca(2+) absorption by the intestine assign essential roles to TRPV6 and calbindin-D(9K) . However, studies with gene-knockout mice challenge this view. Something fundamental is missing. The...
3.
Mace O, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, et al.
J Physiol
. 2008 Nov;
587(1):195-210.
PMID: 19001049
T1R taste receptors are present throughout the gastrointestinal tract. Glucose absorption comprises active absorption via SGLT1 and facilitated absorption via GLUT2 in the apical membrane. Trafficking of apical GLUT2 is...
4.
Kellett G, Brot-Laroche E, Mace O, Leturque A
Annu Rev Nutr
. 2008 Apr;
28:35-54.
PMID: 18393659
Intestinal glucose absorption comprises two components. One is classical active absorption mediated by the Na+/glucose cotransporter. The other is a diffusive component, formerly attributed to paracellular flow. Recent evidence, however,...
5.
Mace O, Affleck J, Patel N, Kellett G
J Physiol
. 2007 May;
582(Pt 1):379-92.
PMID: 17495045
Natural sugars and artificial sweeteners are sensed by receptors in taste buds. T2R bitter and T1R sweet taste receptors are coupled through G-proteins, alpha-gustducin and transducin, to activate phospholipase C...
6.
Morgan E, Mace O, Affleck J, Kellett G
J Physiol
. 2007 Feb;
580(Pt. 2):593-604.
PMID: 17272350
We have proposed a model of intestinal glucose absorption in which transport by SGLT1 induces rapid insertion and activation of GLUT2 in the apical membrane by a PKC betaII-dependent mechanism....
7.
Mace O, Morgan E, Affleck J, Lister N, Kellett G
J Physiol
. 2007 Feb;
580(Pt. 2):605-16.
PMID: 17272349
Glucose absorption in rat jejunum involves Ca(2+)- and PKC betaII-dependent insertion of GLUT2 into the apical membrane. Ca(2+)-induced rearrangement of the enterocyte cytoskeleton is thought to enhance paracellular flow. We...
8.
Kellett G
Am J Physiol Regul Integr Comp Physiol
. 2006 Oct;
292(2):R860-1.
PMID: 17068157
No abstract available.
9.
Bailey P, Boyd C, Collier I, George J, Kellett G, Meredith D, et al.
Chem Commun (Camb)
. 2006 Jan;
(3):323-5.
PMID: 16391748
A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.
10.
Bailey P, Boyd C, Collier I, Kellett G, Meredith D, Morgan K, et al.
Org Biomol Chem
. 2005 Nov;
3(22):4038-9.
PMID: 16267577
The stereochemistry of thiodipeptides of proline [e.g. Ala-Psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.